Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 201-210 of 2,298 results
Journal of Neuroinflammation, 2014 • April 5, 2014
This study investigated the effect of the specific EGFR inhibitor PD168393 on reactive astrogliosis and proinflammatory cytokine secretion of reactive astrocytes in a scratch injury in vitro model and...
KEY FINDING: EGFR phosphorylation parallels astrocyte activation, and the EGFR inhibitor PD168393 effectively inhibited scratch-induced reactive astrogliosis and proinflammatory cytokine/mediator secretion of reactive astrocytes in vitro.
Exp Neurol, 2014 • June 1, 2014
This study investigates the role of dbx1a-expressing radial glial progenitors in spinal cord regeneration in zebrafish larvae. The researchers demonstrate that these progenitors persist beyond embryog...
KEY FINDING: The dbx1a:GFP reporter labels radial glial progenitors in the zebrafish spinal cord beyond embryogenesis, indicating their prolonged presence and potential role in regeneration.
J. Exp. Med., 2014 • May 5, 2014
This study investigates the role of B-RAF kinase in promoting axon growth and regeneration in both the peripheral and central nervous systems using conditional gain-of-function mouse models. The resea...
KEY FINDING: Conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient to drive the growth of long-range peripheral sensory axon projections in vivo without upstream neurotrophin signaling.
Exp Neurol, 2014 • July 1, 2014
This study replicated key parts of a previous study on neural stem cell (NSC) transplants after spinal cord injury (SCI). The researchers confirmed that NSC transplants can fill lesion cavities and ex...
KEY FINDING: NSC transplants can fill lesion cavities in the spinal cord after complete transection, but the extent of engraftment varied depending on the transplantation method used.
PLoS ONE, 2014 • April 18, 2014
This study identifies legumain as an essential component for successful spinal cord regeneration in adult zebrafish after complete spinal cord transection. The researchers found that legumain is upreg...
KEY FINDING: Legumain expression is upregulated in neurons of regenerative nuclei (NMLF and IMRF) during axon regrowth/sprouting after spinal cord injury.
The Journal of Neuroscience, 2014 • April 23, 2014
The study demonstrates that peripheral nerve injury induces a global increase in axonal transport, extending to the central branch of DRGs. This increase in axonal transport supports the regeneration ...
KEY FINDING: A peripheral conditioning lesion increases the anterograde transport of cytoskeleton components, metabolic enzymes and axonal regeneration enhancers in the central branch of DRGs.
ADVANCES IN WOUND CARE, 2014 • February 1, 2014
Nervous system injuries, whether in the CNS or PNS, often lead to poor outcomes. Electric fields (EFs) are being explored as a therapeutic approach to enhance nerve regeneration. EFs have demonstrated...
KEY FINDING: Exogenous EFs have shown neuroprotective effects in various eye injury models, including traumatic injury and glaucoma.
J. Cell. Mol. Med., 2014 • July 1, 2014
This study investigates the role of TGF-β1 signaling in the adult neurogenic niche, focusing on its impact on neural stem cell quiescence and neuronal differentiation. The research demonstrates that T...
KEY FINDING: TGF-b1 signalling in the adult neurogenic niche contributes to stem cell quiescence, and to neuronal differentiation, maturation and survival of newly generated cells.
Stem Cell Rev and Rep, 2014 • May 8, 2014
This study investigates the guided migration of embryonic stem cell (ESC) derived presumptive motor neurons in an applied electric field (EF). The results showed that neural precursors migrated toward...
KEY FINDING: Neural precursors migrated toward the cathode pole of applied electric fields.
Neurosci Bull, 2014 • August 1, 2014
This review summarizes recently-completed clinical trials using cell-mediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells. Specifically, clinical studies...
KEY FINDING: Current transplantation therapies are relatively safe and have provided varying degrees of neurological recovery in SCI patients.