Cell Calcium, 2014 · DOI: 10.1016/j.ceca.2014.04.004 · Published: July 1, 2014
Tissue regeneration involves replenishing damaged cells, differentiating cells appropriately, and integrating them into functional tissues. Amphibian larvae can regenerate tails completely, unlike adult humans with limited spinal cord and muscle repair. Muscle cell precursors in regenerating tails exhibit calcium transients dependent on calcium release. Blocking these transients impairs muscle regeneration, preventing satellite cell activation and proliferation, leading to deficient muscle replenishment. Calcium-mediated activity is critical for the early stages of muscle regeneration. Understanding this may aid in developing effective therapies for tissue repair.
Understanding the role of calcium signaling in muscle regeneration may lead to new therapies for tissue repair.
This study provides insights into the cellular and molecular mechanisms underlying muscle regeneration.
The results may explain the beneficial effects of functional electrical stimulation for atrophic muscle regeneration in humans.