Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 191-200 of 2,298 results
J. Vet. Med. Sci., 2014 • February 21, 2014
The study investigates the therapeutic potential of canine BMSC transplantation in mice with SCI. Results showed that BMSC therapy improved hind limb function and induced Nestin-positive cells at the ...
KEY FINDING: Canine BMSC transplantation enhanced functional recovery of the hind limbs in mice with SCI.
Cell Death and Differentiation, 2014 • February 21, 2014
This study investigates the role of Galectin-1 (Gal-1) in promoting axonal regeneration and functional recovery after spinal cord injury (SCI). The results demonstrate that Gal-1 binds to the NRP-1/Pl...
KEY FINDING: Galectin-1 (Gal-1) promotes full locomotor functional recovery and that an early intervention with this lectin was sufficient to prevent hindlimb loss of function after SCI.
Journal of Extracellular Vesicles, 2014 • February 19, 2014
This study investigates the effects of extracellular vesicles derived from muscle cells on motor neuron survival and neurite outgrowth, using the C2C12 muscle cell line and the NSC-34 motor neuron cel...
KEY FINDING: Extracellular vesicles from muscle cells significantly increase the average neurite length per neuron in motor neuron cultures.
Tissue Engineering, 2014 • March 19, 2014
Substantial progress has been made in improving nerve function in SCI patients through nerve tissue regeneration. This perspective provides an overview of SCI research and tissue-engineered nerve rege...
KEY FINDING: Progress has been made in using cell therapy, including embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), for nerve regeneration in SCI patients.
Neurosurgery, 2014 • July 1, 2014
This study investigates the role of NgR1 in limiting axon regeneration after spinal cord injury (SCI). Using mice with varying degrees of NgR1 deficiency and SCI severity, the research aimed to clarif...
KEY FINDING: The level of functional recovery is affected by the degree of injury suffered, with NgR1 ablation leading to significant recovery in locomotor function following severe SCI.
Stem Cell Reports, 2014 • March 11, 2014
The study demonstrates the existence of intrinsically active neurons (IANs) in pluripotent stem cell-derived neuronal networks, using mouse embryonic stem cells. These IANs are functionally integrated...
KEY FINDING: Pluripotent stem cell-derived neuronal networks contain intrinsically active neurons (IANs) that remain active after blocking fast synaptic communication.
Neuroscience Letters, 2014 • March 12, 2014
This study investigates the use of a novel fibrin scaffold for delivering MSCs to injured spinal cords, aiming to improve cell integration and control compared to intraspinal injection. The results sh...
KEY FINDING: Fibrin scaffold delivery of MSCs results in longitudinally-aligned layers of cells at the injury site.
Brain and Behavior, 2014 • March 1, 2014
This editorial highlights a study investigating the effects of subcutaneous FGF2 administration on spinal cord injury recovery in mice, focusing on its potential to reduce inflammation and promote reg...
KEY FINDING: FGF2 has been shown to have multiple neural-promoting effects on the developing and adult nervous system, including inducing and regulating the proliferation of neural stem cells and precursors.
Brain and Behavior, 2014 • March 1, 2014
This study investigates the effects of Fgf2 treatment on spinal cord injury (SCI) in mice, focusing on its impact on glial scarring, neuronal survival, and neurite outgrowth. The research aims to iden...
KEY FINDING: Fgf2 treatment decreases the expression of TNF-α, reduces monocyte/macrophage infiltration, and decreases gliosis at the lesion site after spinal cord injury in mice.
Molecular Brain, 2014 • March 31, 2014
In 2006, we demonstrated that mature somatic cells can be reprogrammed to a pluripotent state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there has been an enor...
KEY FINDING: When mouse or human iPS cells were induced to form NS/PCs and were transplanted into mouse or non-human primate SCI models, long-term restoration of motor function was induced, without tumorigenicity, by selecting a suitable iPS cell line.