Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury

J. Vet. Med. Sci., 2014 · DOI: 10.1292/jvms.13-0587 · Published: February 21, 2014

Regenerative Medicine Neurology Veterinary Medicine

Simple Explanation

This study explores the use of canine bone marrow stromal cells (BMSCs) to treat spinal cord injury (SCI) in mice. The researchers transplanted canine BMSCs into mice with SCI and observed the effects on functional recovery. The study found that mice with SCI who received BMSC transplants showed enhanced functional recovery of their hind limbs compared to a control group. The researchers also noted the presence of Nestin-positive cells in the lesion area of mice treated with BMSCs, suggesting a possible mechanism for the observed functional recovery.

Study Duration

4 weeks

Participants

24 female severe combined immunodeficiency mice

Evidence Level

Not specified

Key Findings

1
Canine BMSC transplantation enhanced functional recovery of the hind limbs in mice with SCI.
2
Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs.
3
Transplanted cells in this study were detected in SCI lesion site (T10) and lumbar cord in mice at genomic level

Research Summary

The study investigates the therapeutic potential of canine BMSC transplantation in mice with SCI. Results showed that BMSC therapy improved hind limb function and induced Nestin-positive cells at the lesion site. The findings suggest that canine BMSCs promote functional recovery after SCI, possibly by promoting migration of nestin-positive cells.

Practical Implications

Potential Therapy for SCI

Canine BMSC transplantation may offer a therapeutic approach for spinal cord injury.

Mechanism of Action

The study suggests a role for Nestin-positive cells in BMSC-mediated SCI recovery.

Further Research

Further research is needed to optimize cell sources, number of cells, and timing of transplantation.

Study Limitations

1
The xenotransplantation model used in this study may not necessarily reflect SCI in canines.
2
This study was not a double-blind design
3
The in vivo physiological function of nestin remains unknown.

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