The role of FGF2 in spinal cord trauma and regeneration research

This editorial discusses an article focusing on the potential of fibroblast growth factor 2 (FGF2) to improve functional recovery after spinal cord injury (SCI) in mice. The study hypothesized that FGF2 could reduce inflammation and promote tissue regeneration. The central nervous system (CNS) has limited self-repair capabilities compared to the peripheral nervous system (PNS), primarily due to differences in glial cell function. Inhibitory molecules and limited growth factor production in the CNS hinder neurite outgrowth after injury. Research has focused on growth factors like FGF2 as potential treatments to improve neuronal survival and regeneration in the injured spinal cord. FGF2 has demonstrated neural-promoting effects and can regulate neural stem cell proliferation and differentiation.

• 1
  FGF2 has been shown to have multiple neural-promoting effects on the developing and adult nervous system, including inducing and regulating the proliferation of neural stem cells and precursors.
• 2
  In mouse models, FGF2 reduces inflammation by decreasing inflammatory cells and markers such as macrophages, microglia, and CD8 T-cells, and limits CD44-mediated leukocyte migration.
• 3
  Intrathecal administration of FGF2 in rats with SCI has been associated with earlier and more pronounced hind limb movements and coordination compared to control groups.