Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,971-1,980 of 2,298 results
J. Biol. Chem., 2020 • January 13, 2020
This study characterizes the functions of various NKX2-2 structural domains in the oligodendrocyte differentiation process, demonstrating that the CT domain, like the TN domain, also behaves as a tran...
KEY FINDING: The N-terminal Tinman domain and C-terminal domain of NKX2-2 synergistically promote oligodendrocyte differentiation.
Brain and Behavior, 2020 • January 1, 2020
Spinal cord injuries are devastating, and spinal cord regeneration has not yet been achieved. Research during the past 30 years reveals that growth factors, along with spinal cord extracellular matrix...
KEY FINDING: Glycosaminoglycans interact with hundreds of extracellular growth factors, chemokine, cytokines, proteases, and protease inhibitors and are essential for animal development.
Data in brief, 2020 • January 3, 2020
This data article presents quantifications of glycine-immunoreactive neurons in the spinal cord of larval sea lampreys following complete spinal cord injury. The study quantifies the number of glycine...
KEY FINDING: Glycine immunoreactivity is acutely lost in glycinergic neurons immediately following spinal cord injury.
PLOS ONE, 2020 • January 21, 2020
This study demonstrates that targeting chondroitinase ABC (ChABC) to the axon markedly enhances its ability to promote neurite extension and sprouting in neuronal cultures. The enhanced neurite outgro...
KEY FINDING: Targeting ChABC to the axon significantly enhances its ability to promote neurite outgrowth compared to non-targeted ChABC.
Biophysical Journal, 2020 • January 21, 2020
This article discusses a study on zebrafish spinal cord injury and repair, focusing on the biochemomechanical microenvironment changes following transection. The key finding is that spinal cord tissue...
KEY FINDING: Gray matter in the spinal cord is approximately twice as stiff as white matter in both healthy and injured states.
Scientific Reports, 2020 • January 21, 2020
This study identifies 2-methoxy-1,4-naphthoquinone (RAD618) as a natural compound that enhances the viability of olfactory ensheathing cells (OECs), which are crucial for neural repair. RAD618 stimula...
KEY FINDING: 2-methoxy-1,4-naphthoquinone (RAD618) strongly stimulates OEC proliferation over several weeks in culture while maintaining the OEC phenotype.
Communications Biology, 2020 • January 14, 2020
The review explores the diversity of regenerative mechanisms in the central nervous system across different species, focusing on the molecular control of regeneration, particularly in axolotls. It hig...
KEY FINDING: Axolotls activate glial cell division and migration to fill in the missing portion of the neural tube after spinal cord transection, making it impossible to distinguish old from new tissue morphologically.
Oxidative Medicine and Cellular Longevity, 2020 • January 7, 2020
This study investigates the role of metformin in antioxidant and neuronal regeneration after SCI, finding that it promotes microtubule stabilization and reduces apoptosis by activating the PI3K/Akt pa...
KEY FINDING: Metformin improves functional recovery after SCI in rats, as evidenced by improved BBB scores and reduced tissue damage.
The EMBO Journal, 2020 • February 3, 2020
Here we show that the matricellular protein CCN1, which is selectively expressed in the ependymal cells, constrains the niche capacity, maintaining a balanced number of NSCs in the adult V-SVZ. Our re...
KEY FINDING: CCN1 is specifically expressed in ependymal cells in the adult V-SVZ.
Journal of Medicine and Life, 2019 • October 1, 2019
The study aimed to replicate Brunelli's CNS-PNS grafting paradigm in rats, investigating the potential benefits of graft-induced neuroregeneration of denervated skeletal muscle and the effect of Cereb...
KEY FINDING: Brunelli’s concept was successfully replicated, demonstrating the first graft induced existence of cholinergic and glutamatergic neurotransmission in denervated grafted muscles.