Data on the recovery of glycinergic neurons after spinal cord injury in lampreys

Data in brief, 2020 · DOI: https://doi.org/10.1016/j.dib.2019.105092 · Published: January 3, 2020

Spinal Cord Injury Regenerative Medicine Neurology

Simple Explanation

This study uses immunohistochemical methods to quantify changes in the number of glycine-immunoreactive neurons in lampreys after spinal cord injury. The data show that glycine immunoreactivity is lost in glycinergic neurons immediately after injury. The number of glycine-immunoreactive neurons recovers in the following two weeks after injury.

Study Duration

1 hour to 10 weeks

Participants

33 larval sea lampreys

Evidence Level

Not specified

Key Findings

1
Glycine immunoreactivity is acutely lost in glycinergic neurons immediately following spinal cord injury.
2
The number of glycine-immunoreactive neurons recovers within two weeks post-injury.
3
Glycine-ir cell numbers are recovered to control levels after the statistically signiﬁcant acute loss of glycine immunoreactivity

Research Summary

This data article presents quantifications of glycine-immunoreactive neurons in the spinal cord of larval sea lampreys following complete spinal cord injury. The study quantifies the number of glycine-immunoreactive neurons located in the rostral and caudal stumps of the spinal cord. The data reveal the loss of glycine immunoreactivity immediately after injury and the subsequent recovery of glycine-immunoreactive neurons within two weeks.

Practical Implications

Comparative Neurotransmitter Recovery

Data can be compared with recovery data from other neurotransmitter systems in both regenerating and non-regenerating vertebrates.

Understanding Locomotion Restoration

The data set is valuable for researchers studying factors influencing spontaneous restoration of locomotion after spinal cord injury in regenerating animal models.

Facilitating Recovery in Non-regenerating Models

This data is of interest for investigating the role of glycinergic neurons in recuperation from spinal cord injury.

Study Limitations

1
Small sample sizes in some experimental groups.
2
The study focuses solely on glycinergic neurons; other neurotransmitter systems may also play a role.
3
Findings are specific to larval sea lampreys and may not directly translate to other species.

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