Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,961-1,970 of 2,298 results
J Transl Med, 2019 • December 20, 2019
The study systematically compares pooled HPL-based medium preparations (pHPL) and two differentially fibrinogen-depleted variants and FBS with respect to biochemical composition. Cell proliferation wa...
KEY FINDING: pHPL-supplemented media supported proliferation of WAT- and UC-derived stromal cells significantly better than FBS.
Asian Journal of Transfusion Science, 2019 • December 3, 2019
This randomized controlled trial evaluated the effectiveness of bone marrow-derived mononuclear stem cells (BM-MNSCs) as an adjuvant to conventional treatment for acute spinal cord injury (SCI). The s...
KEY FINDING: Participants in Group 1 (conventional surgery with stem cells) showed significant improvement in AIS grade, sensory scores, and motor scores after 1 year (P < 0.001).
Stem Cell Research & Therapy, 2020 • January 9, 2020
The study aimed to assess the consistency, potency, and stability of PBMC secretome batches produced under GMP, by comparing different batches and analyzing physicochemical and biological parameters, ...
KEY FINDING: Inter-batch differences in the bioactive components and secretome properties were small despite considerable differences in protein concentrations and potencies between individual donor secretomes.
International Journal of Surgery Case Reports, 2020 • December 12, 2019
This case report presents the successful treatment of a vertebral body defect (VBD) in a 27-year-old female using umbilical cord-derived mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite s...
KEY FINDING: The patient could walk and had no pain three months post-surgery.
Exp Neurobiol, 2019 • December 1, 2019
This study investigates the therapeutic potential of human neural stem/progenitor cells (hNSPCs) transduced with glial cell line-derived neurotrophic factor (GDNF) in a rat model of traumatic spinal c...
KEY FINDING: GDNF-hNSPCs showed robust engraftment, long-term survival, an extensive distribution, and increased differentiation into neurons and oligodendroglial cells compared to controls.
Experimental Biology and Medicine, 2020 • January 1, 2020
This study investigates the therapeutic potential of neural stem cell-derived exosomes (NSCs-Exos) in promoting spinal cord functional recovery after injury by enhancing angiogenesis. The key finding ...
KEY FINDING: NSCs-Exos enhance the angiogenic activities of SCMECs, promoting migration, proliferation, and tube formation in vitro.
Neural Regen Res, 2020 • January 28, 2020
This study protocol outlines a clinical trial to investigate the use of human umbilical cord mesenchymal stem cells (hUC-MSCs) for treating spinal cord injury (SCI) in the early chronic phase. The tri...
KEY FINDING: The primary goal is to see if hUC-MSCs can improve the ASIA (American Spinal Injury Association) total score in patients with early chronic SCI.
Cell Reports, 2020 • January 7, 2020
This study investigates why regeneration following spinal root avulsion is broadly unsuccessful. It identifies that regenerating DRG neurons fail to recapitulate developmental paradigms of actin-based...
KEY FINDING: Regenerating DRG sensory axons do not initiate actin-based invasion components during re-entry into the spinal cord following avulsion-like injuries.
Neural Development, 2020 • January 5, 2020
The Nogo pathway stabilizes CNS circuitry, limiting plasticity and functional recovery after spinal cord damage. Anti-Nogo antibodies improve anatomical and functional recovery, particularly with acut...
KEY FINDING: Anti-Nogo antibodies have consistently demonstrated improvement in motor function recovery in rats and primates, including fine finger control.
Front. Cell Dev. Biol., 2019 • December 20, 2019
This study demonstrates the formation of pinwheel structures in spinal cord and SVZ tissue-derived neurospheres cultured in vitro, similar to those found in the neurogenic niche of the adult brain. Th...
KEY FINDING: Spinal cord and SVZ tissue-derived neurospheres cultured in vitro form pinwheel structures reminiscent of those present in the SVZ in vivo.