Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,951-1,960 of 2,298 results
Brazilian Journal of Medical and Biological Research, 2019 • December 1, 2019
This study investigated the effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on spinal cord injury (SCI) in rats. The results showed that injection of mi...
KEY FINDING: Injection of miRNA-29b exosomes significantly increased miRNA-29b expression in spinal cord tissues of SCI rats.
Frontiers in Bioengineering and Biotechnology, 2019 • November 27, 2019
The review discusses the challenges in bone regeneration, especially in patients with decreased tissue regeneration capacity. It highlights the use of mesenchymal stromal cells (MSCs) and MSC-based ti...
KEY FINDING: MSCs can be isolated from various sources, each with unique characteristics and regenerative potential, influencing the choice of cell source and manipulation techniques for specific applications.
Stem Cell Research & Therapy, 2019 • December 1, 2019
This study introduces NRLM, a culture medium for clinical hMSC expansion, which enhances yields and therapeutic effects for SCI repair. NRLM was shown to increase the fold expansion of MSCs and marked...
KEY FINDING: NRLM-CM had superior inflammation reduction and neurite regeneration effects in vitro compared to standard culture medium.
Frontiers in Neuroscience, 2019 • November 26, 2019
This study investigates the impact of dimethylsulfoxide (DMSO) on oligodendrogenesis using adult rat neural stem and progenitor cells (NSPCs). The key finding is that DMSO inhibits oligodendrogenesis ...
KEY FINDING: A concentration of 1% DMSO robustly suppressed oligodendrogenesis and drove the fate of differentiating NSPCs toward astrogenesis.
Cell Bioscience, 2020 • September 15, 2020
MSCs from bone marrow, adipose tissue, and umbilical cord have been used clinically to treat SCI, with many trials focusing on chronic SCI patients paralyzed for years. MSC therapy is generally safe b...
KEY FINDING: MSCs suppress inflammation, secrete paracrine factors that protect axons and promote regeneration, and differentiate into nerve cells.
Frontiers in Neurology, 2019 • November 29, 2019
This study investigated the potential of extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) to replicate the anti-inflammatory and anti-scarring effects of their parental cells...
KEY FINDING: MSC-EVs effectively reduced neuroinflammation in a rat model of spinal cord injury, comparable to the effects of the parental MSCs.
Stem Cell Research & Therapy, 2019 • November 5, 2019
The study revealed that lncRNA Neat1 is involved in regulating Wnt/β-catenin signaling that is activated by miR-124 in SC-NPCs. LncRNA Neat1 was also found to play an important role in regulating neur...
KEY FINDING: LncRNA Neat1 is involved in regulating Wnt/β-catenin signaling activated by miR-124 in SC-NPCs.
Biology Open, 2019 • December 2, 2019
This paper presents an algorithm that automatically characterizes the level of damage to the spinal cord of a Xenopus laevis froglet by analyzing swimming videos. The algorithm measures the position o...
KEY FINDING: The system effectively characterizes spinal cord damage with 97% accuracy by tracking limb movements and extracting kinematic features.
Biophysical Journal, 2020 • January 21, 2020
This study investigates the mechanical properties of the adult zebrafish spinal cord during regeneration after complete spinal cord transection using atomic force microscopy. The researchers mapped the...
KEY FINDING: In uninjured zebrafish, gray matter regions of the spinal cord are stiffer than white matter regions.
Stem Cells International, 2019 • December 2, 2019
The study investigates a novel approach combining cell transplantation and nerve transfer to address challenges in peripheral nerve injury repair. Transplanted embryonic spinal cord cells prevented Sc...
KEY FINDING: Transplanted embryonic spinal cord cells survived and differentiated into neurons within the injured nerve's distal stump, preventing chronic degeneration of Schwann cells.