Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,941-1,950 of 2,298 results
Frontiers in Immunology, 2019 • November 1, 2019
This study identifies foamy macrophages in the reactive Axolotl spinal cord meninges, revealing their participation in spinal cord regeneration. These cells accumulate in fibrotic meninges during amph...
KEY FINDING: Foam cells (foamy macrophages) accumulate in the invasive fibrotic meninges during gap regeneration of transected adult Axolotl spinal cord and may act beneficially.
Biomolecules, 2019 • December 1, 2019
This study comparatively assesses the therapeutic potential of mesenchymal stem cells (MSCs) from bone marrow (BM-MSCs), adipose tissue (AD-MSCs), and dental pulp (DP-MSCs) in rat and pig models of sp...
KEY FINDING: In rats, AD-MSCs significantly improved locomotor activity, nerve conduction, reduced tissue damage, and modulated immune cell activation compared to bone marrow or dental pulp MSCs.
J. Biol. Chem., 2020 • November 20, 2019
This study demonstrates that Nogo-A is proteolytically cleaved into a 24-kDa C-terminal fragment, which is then secreted via exosomes. The exosomal Nogo-A fragment contains the Nogo-66 domain, which i...
KEY FINDING: Nogo-A is cleaved into a 24-kDa C-terminal fragment that is released via exosomes.
Frontiers in Immunology, 2019 • November 8, 2019
The study aimed to understand the heterogeneity among BMSC specimens and whether donor-specific variability in morphological and functional parameters could be explained by donor age and comorbidities...
KEY FINDING: BMSCs from both adult and elderly donors met standard criteria for MSCs, exhibiting similar morphology, growth kinetics, gene expression profiles, and differentiation capacity.
The Journal of Clinical Investigation, 2020 • January 1, 2020
Axon regeneration failure causes neurological deficits and long-term disability after spinal cord injury (SCI). Here, we found that the α2δ2 subunit of voltage-gated calcium channels negatively regula...
KEY FINDING: The α2δ2 subunit negatively regulates axon growth and regeneration of corticospinal neurons.
Annals of Translational Medicine, 2019 • October 1, 2019
This study investigates the role of HSC70 in C2C12 myoblast differentiation, finding that HSC70 is up-regulated during differentiation. The research demonstrates that HSC70 knockdown inhibits myoblast...
KEY FINDING: HSC70 expression is significantly up-regulated during C2C12 myoblast differentiation.
International Journal of Molecular Sciences, 2019 • December 2, 2019
Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and a...
KEY FINDING: HGF minimizes secondary damage in the acute phase of SCI through its anti-inflammatory and anti-fibrotic activities.
Biochem Biophys Res Commun, 2020 • February 19, 2020
This study investigates the role of JunB in Xenopus tail regeneration, revealing its importance in regulating cell proliferation. The research demonstrates that JunB expression is activated and sustai...
KEY FINDING: The expression of junb is rapidly activated and sustained during tail regeneration.
J Tissue Eng Regen Med, 2020 • February 5, 2020
This study demonstrates the potential of a novel integrated scaffold loaded with BMSCs to promote spinal cord regeneration through mechanical guidance and neuroprotective mechanisms. The scaffold comb...
KEY FINDING: The integrated scaffold guided the regeneration of axons, especially serotonin receptor 1A receptor-positive axonal tracts.
Neural Regen Res, 2020 • December 10, 2019
This study introduces a method for directly tracing and quantifying sensory axon regeneration in vivo using electroporation and fluorescent labeling. The research provides a detailed time course of se...
KEY FINDING: Sensory axons regenerate slowly during the first day after injury but show steady growth from the second day onwards.