Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,931-1,940 of 2,298 results
Stem Cells International, 2019 • September 15, 2019
This article reviewed roles of DFCs in tooth development, their properties, and clinical application potentials, thus providing a novel guidance for tissue engineering. The establishment of tooth root...
KEY FINDING: DFCs robustly expressed parathyroid hormone-related peptide (PTHrP) during tooth root formation and after tooth eruption, and PTHrP+ DFCs differentiated into PDLCs, alveolar cryptal bone osteoblasts, and cementoblasts in acellular cementum
Advances in Wound Care, 2019 • November 1, 2019
Cell therapeutics is a promising approach for nerve regeneration, playing roles in neuron and glial cell replacement, neurotrophic factor and anti-inflammatory cytokine secretion, tissue retention and...
KEY FINDING: Schwann cells (SCs) promote neuroprotection, reduce cyst and glial scar formation, and enhance axonal regeneration and myelinization, leading to improved functional outcomes after SCI.
Neural Regen Res, 2020 • October 18, 2019
This study investigates the protective effects of rhodioloside (Rho) and bone marrow mesenchymal stem cells (BMSCs) infected with HIF-1-expressing adenovirus on acute spinal cord injury (SCI) in a rat...
KEY FINDING: The group treated with both rhodioloside and HIF-1-expressing MSCs showed the highest combined behavioral score, indicating better motor function recovery.
Neural Regen Res, 2020 • October 18, 2019
This meta-analysis aimed to determine the efficacies of NSC transplantation on functional recovery following SCI using a clinically relevant, standardized rat model of contusion SCI. The meta-analysis...
KEY FINDING: Transplanted NSCs can improve motor function recovery of rats following contusion SCIs, to a moderate extent.
Exp Neurol, 2020 • January 1, 2020
This study investigates the interaction between sensory and motor axons during nerve regeneration using an in vitro model where axons are color-coded by modality. The findings demonstrate that sensory...
KEY FINDING: Sensory axons regenerate more rapidly than motor axons in the in vitro model.
Cells, 2019 • October 30, 2019
The study investigated the effect of autophagy induction by genetic and pharmacological manipulation on motor nerve regeneration using models of nerve axotomy and compression. ATG5 or NAD+-dependent de...
KEY FINDING: Overexpression of ATG5 in spinal motor neurons stimulates mTOR-independent autophagy and improves motor axonal regeneration.
Frontiers in Pharmacology, 2019 • October 16, 2019
The study demonstrates a novel role for FGF10 in improving sensory and motor functional recovery, enhancing axonal regrowth and remyelination, and increasing the expression of functional proteins afte...
KEY FINDING: FGF10 continuously enhances the recovery of locomotor and sensory function in acute PNI.
Neural Regen Res, 2020 • November 8, 2019
This study examined the expression of Slit1–3 and Robo1–2 in the adult mouse peripheral nervous system after sciatic nerve transection injury using qRT-PCR, western blot, and immunostaining. The study...
KEY FINDING: In the dorsal root ganglion (DRG), Slit1-3 and Robo1-2 mRNA expression were initially downregulated within 4 days after injury, but Slit1-3 mRNA expression remained upregulated during regeneration from 4-14 days after injury.
Neural Regeneration Research, 2020 • November 8, 2019
This study investigates the efficacy of a 3D-bioprinted collagen/silk fibroin scaffold (3D-CF) combined with neural stem cells (NSCs) in promoting nerve regeneration after spinal cord injury (SCI) in ...
KEY FINDING: Implantation of the 3D-CF combined with NSCs resulted in significantly higher neurological scores compared to other groups, indicating improved motor function recovery.
Cell Transplantation, 2019 • September 27, 2019
This review highlights that the survival of transplanted cells is crucial for successful outcomes following OEC transplantation into the injured spinal cord and identifies key factors influencing OEC ...
KEY FINDING: OEC survival is influenced by injury type, cell source, co-transplantation with other cells, cell number/concentration, delivery method, and the time between injury and transplantation.