Regenerative Medicine Research

KEY FINDING: Six miRNAs (hsa-miR-19b-3p, hsa-miR-192-5p, hsa-miR-25-3p, hsa-miR-19a-3p, hsa-miR-18b-5p, hsa-miR-93-5p) were exclusively repressed in patients with degenerative RCTs compared to controls and chronic tendinopathy.

KEY FINDING: Spectrin may promote axonal regeneration after spinal cord injury in zebrafish.

KEY FINDING: KCC2 protein is lost from the somatodendritic membrane of axotomized spinal cord motoneurons after downregulation of kcc2 mRNA expression.

KEY FINDING: Peripheral nerve injury leads to morphological, molecular and gene expression changes in the spinal cord and dorsal root ganglia, some of which have positive impact on the survival of neurons and nerve regeneration, while the effect of others is the opposite.

KEY FINDING: High-dose NSPC transplantation improved the injury microenvironment by increasing anti-inflammatory cytokines and neurotrophic factors in the acute phase of severe SCI.

KEY FINDING: ECM hydrogels, particularly in solubilized form, can modulate inflammation in LPS-stimulated microglial cells, with spinal cord-derived hydrogels reducing the Nos2/Arg1 ratio and bone-derived hydrogels reducing Tnf expression.

KEY FINDING: Loss of Limk1 promotes spinal motor axon outgrowth, suggesting temporal guidance mechanisms are widely used during development.

KEY FINDING: FR effectively labels ascending fibers in the dorsal columns of the rat spinal cord, including regenerated fibers crossing injury sites.

KEY FINDING: Salamanders exhibit considerable variation in life history, development, physiology, and morphology, more than other tetrapod groups, including variations in limb morphology and digit number.

KEY FINDING: Pramipexole, a dopamine agonist, was identified as a specific enhancer of zTreg recruitment to injured tissue in zebrafish.