Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,911-1,920 of 2,298 results
Neuron, 2019 • September 25, 2019
The study identifies ADF/Cofilin-mediated actin turnover as a molecular mechanism to induce axon regeneration, mimicking processes during development. Conditioning increases actin dynamics by enhancin...
KEY FINDING: Elevated actin turnover is essential for regenerative growth of axons following a conditioning lesion.
The Journal of Neuroscience, 2019 • October 16, 2019
This study demonstrates that activating Epac2, a downstream effector of cAMP, enhances neurite outgrowth in vitro, even in an inhibitory environment. Using a novel biomaterial-based drug delivery syst...
KEY FINDING: Epac2 activation significantly enhanced neurite outgrowth of postnatal rat cortical neurons and markedly overcame the inhibition by chondroitin sulfate proteoglycans and mature astrocytes on neuron growth in vitro.
ENEURO, 2019 • August 19, 2019
This study investigated the effect of promoting axon regeneration on respiratory function after cervical spinal cord injury (SCI) in rats. Systemic administration of a PTEN antagonist peptide (PAP4) p...
KEY FINDING: Systemic administration of PAP4 promoted significant functional recovery of diaphragmatic respiratory function after cervical SCI.
TISSUE ENGINEERING: Part B, 2019 • October 23, 2019
Spinal cord injury (SCI) results in loss of motor, sensory, and autonomic functions, with limited regenerative capacity in the central nervous system (CNS). Current SCI treatment is mostly conservativ...
KEY FINDING: No effective regenerative treatment has been developed for spinal cord injury to date, despite advances in regenerative medicine and bioengineering.
Expert Opin Ther Targets, 2019 • September 1, 2019
Researchers have made significant progress in understanding the pathophysiology of SCI and in developing effective preclinical therapeutic strategies by targeting diverse cellular and molecular mechan...
KEY FINDING: Early surgical decompression appears to improve neurological function in preclinical and clinical studies.
Nature Communications, 2019 • September 6, 2019
The spinal injury scar is a complex entity comprising various cell types and extracellular components that interplay to modulate tissue repair and regeneration after spinal cord injury. Reactive astro...
KEY FINDING: The spinal injury scar comprises multiple cellular and extracellular components beyond just glial cells, including fibroblasts, immune cells, and extracellular matrix.
BioMed Research International, 2019 • August 4, 2019
This study investigates the effect of the GSK-3 inhibitor TDZD-8 on neuronal regeneration and functional recovery in a rat model of spinal cord injury (SCI). The results indicate that TDZD-8 treatment...
KEY FINDING: TDZD-8 significantly inhibited neuronal apoptosis after SCI in rats.
Molecular Therapy, 2019 • December 1, 2019
This study investigates the role of UTX, a histone demethylase, in vascular regeneration following spinal cord injury (SCI). The researchers found that UTX expression increases in endothelial cells po...
KEY FINDING: UTX expression increases in endothelial cells following spinal cord injury in mice.
International Journal of Molecular Sciences, 2019 • September 10, 2019
This study investigates the regenerative effect of growth hormone (GH) on the retina after excitotoxic damage induced by kainic acid (KA) in chickens. The results showed that GH treatment promoted sig...
KEY FINDING: GH treatment after KA-induced damage significantly restored the thickness of the inner plexiform layer (IPL) and inner nuclear layer (INL) in the retina.
Scientific Reports, 2019 • September 13, 2019
This study successfully generated and characterized c-MycERTAM-transduced human late-adherent olfactory mucosa cells (hOMCs) for potential regenerative applications in spinal cord injury (SCI). Two po...
KEY FINDING: The study successfully generated two c-MycERTAM-derived hOMC populations (PA5 and PA7) through retroviral transduction. These cells incorporated the c-MycERTAM transgene into their genome and expressed the corresponding protein.