Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,901-1,910 of 2,298 results
PNAS, 2019 • June 24, 2019
The study introduces a method to label CNS demyelinating lesions using neutral red (NR) dye, enabling easy identification and dissection of lesions. NR labeling allows for comprehensive analysis of mo...
KEY FINDING: Neutral red (NR) dye effectively labels demyelinated lesions in the CNS of mice in both lysolecithin- and EAE-induced demyelination models.
The EMBO Journal, 2019 • May 22, 2019
The molecular mechanisms discriminating between regenerative failure and success remain elusive. We found that calcium increases in DRG following a regeneration-competent sciatic but not a regeneratio...
KEY FINDING: HDAC3 inhibition promoted neurite outgrowth on both growth-permissive and inhibitory substrates.
Cell Transplantation, 2019 • September 1, 2019
This study demonstrates that NSC transplantation can improve motor function in rats with spinal cord transection (SCT). The observed improvements were associated with nerve regeneration, increased neu...
KEY FINDING: NSC transplantation reduced SCT-induced deficits, including increased NeuN-positive cells (neurons) and decreased apoptotic cells in the spinal cord.
BioMed Research International, 2019 • June 2, 2019
The study investigates the therapeutic potential of nAG protein in a rat model of liver fibrosis induced by carbon tetrachloride (CCL4). Results showed that nAG treatment significantly reduced serum l...
KEY FINDING: CCL4 treatment significantly increased serum levels of hyaluronic acid, PDGF-AB, TIMP-1, laminin, procollagen III N-terminal peptide, and collagen IV-alpha 1 chain.
Front. Mol. Neurosci., 2019 • June 28, 2019
This review summarizes the current understanding of lncRNAs and circRNAs in nerve regeneration, focusing on their roles in peripheral nerve injury and spinal cord injury. The review highlights specifi...
KEY FINDING: LncRNAs and circRNAs play a role in both peripheral nerve injury and spinal cord injury, influencing processes such as neurite outgrowth, Schwann cell modulation, astrocyte proliferation, and neuronal survival.
Frontiers in Genetics, 2019 • July 9, 2019
Here, we summarize recent progress in characterizing neuronal intrinsic and extrinsic chromatin reconfigurations and epigenetic changes triggered by axonal injury that shape neuroplasticity and glial ...
KEY FINDING: Peripheral axotomy of DRG neurons elicits unique chromatin alterations with corresponding transcriptional responses.
Stem Cell Research & Therapy, 2019 • July 11, 2019
Stem cell therapy shows promise for spinal cord injury repair, but challenges remain before clinical application. ESCs face ethical and tumorigenicity concerns, while iPSCs, though avoiding ethical is...
KEY FINDING: NSCs can differentiate into neurons to replace lost ones, creating relay circuits to bridge disrupted tracts, and secrete growth-promoting factors.
Frontiers in Cellular Neuroscience, 2019 • July 24, 2019
This study investigates the pro-neuroregenerative activity of ENDF1, a prenylated flavonoid, on dorsal root ganglion (DRG) neurons in the presence of extracellular matrix (ECM) growth inhibitors. The ...
KEY FINDING: ENDF1 promotes neurite regrowth of DRG neurons despite the presence of inhibitory ECM molecules.
Neural Regen Res, 2019 • December 1, 2019
This study investigates the therapeutic effects of wrapping a completely severed common peroneal nerve in rats with amniotic membrane (AM). The results showed that AM significantly improves nerve func...
KEY FINDING: Amniotic membrane wrapping significantly improved the function of the injured nerve, leading to faster recovery of toe spread function and nerve conduction velocity.
Methods, 2020 • January 15, 2020
Decellularization employs chemical agents, enzymes, and mechanical means to strip cells and lipids from tissue, leaving a non-immunogenic scaffold. Acellular scaffolds offer a unique material consisti...
KEY FINDING: Dysregulation of the extracellular matrix (ECM), specifically scarring, impairs normal cell function and alters the regenerative potential of nervous tissues.