Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve

Peripheral nerve injuries often result from trauma and can lead to motor and sensory dysfunction. Current treatments like sutures and nerve transplants have limitations due to microenvironment imbalances and tissue adhesion. The human amniotic membrane (AM) has been studied for its ability to promote tissue healing, possessing anti-inflammatory, antibacterial, and antiviral properties. It also secretes active factors beneficial for tissue repair. This study investigated whether wrapping a severed nerve in rats with a fresh amniotic membrane could improve nerve regeneration and functional recovery. Results showed significant improvements in nerve function and tissue structure.

• 1
  Amniotic membrane wrapping significantly improved the function of the injured nerve, leading to faster recovery of toe spread function and nerve conduction velocity.
• 2
  The amniotic membrane promoted the recovery of the tibialis anterior muscle and improved its tissue structure, indicating enhanced muscle regeneration.
• 3
  Amniotic membrane wrapping regulated the mRNA expression of key neurotrophic factors and inhibitors associated with axonal regeneration, facilitating nerve repair.