Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,891-1,900 of 2,298 results
eLife, 2019 • May 9, 2019
This study demonstrates that circulating TGF-b1 promotes oligodendrocyte maturation and remyelination in the CNS. The researchers found that decreasing circulating TGF-b1 levels impairs remyelination ...
KEY FINDING: TGF-b1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation.
Scientific Reports, 2019 • May 13, 2019
The study aimed to investigate the influence of heparin on stromal cells derived from bone marrow (BM), umbilical cord (UC), and white adipose tissue (WAT), focusing on cellular uptake, gene expressio...
KEY FINDING: Heparin is internalized by stromal cells in a tissue-dependent manner, with BM- and UC-derived cells internalizing significantly more heparin than WAT-derived cells.
Scientific Reports, 2019 • May 13, 2019
This study investigates the role of CRMP2 phosphorylation in axonal regeneration after optic nerve injury using CRMP2 knock-in mice, where CRMP2 phosphorylation at Ser522 is inhibited. The results ind...
KEY FINDING: Inhibition of CRMP2 phosphorylation suppresses microtubule depolymerization after optic nerve injury.
JOURNAL OF NEUROTRAUMA, 2019 • November 1, 2019
This study examined the effects of transplanting neuroectodermal stem cells into contused spinal cords of rats. The stem cells were delivered either intraspinally or intravenously, and functional outc...
KEY FINDING: Stem cells applied either locally or intravenously induced significantly improved functional recovery compared with their controls.
Stem Cell Research & Therapy, 2019 • May 2, 2019
This study investigated whether bone marrow-derived mesenchymal stem cells (BMMSCs) overexpressing insulin-like growth factor 1 (IGF-1) improved the therapeutic effects of BMMSCs in SCI. The researche...
KEY FINDING: BMMSC-IGF1 transplantation increased cell survival and recruitment of endogenous neural progenitor cells compared to BMMSC- or saline-treated controls.
International Journal of Molecular Sciences, 2019 • August 6, 2019
Regeneration of spinal cord injuries (SCIs) is challenging due to complex pathological events. Neural stem/progenitor cells (NSCs/NPCs) derived from induced pluripotent stem cells (iPSCs) offer a prom...
KEY FINDING: iPSC-derived NPCs can be successfully differentiated and engrafted into SCI animal models, leading to functional recovery of injury.
Communications Biology, 2019 • May 17, 2019
This study identifies genes promoting extent of CNS axon regrowth using laser-mediated axon transection with confocal time-lapse imaging. Regrowing wild-type axons initiate multidirectional sprouting ...
KEY FINDING: PHR directs regrowing axons along the pre-lesional trajectory and across the transection site in zebrafish spinal axons.
International Journal of Molecular Sciences, 2019 • May 31, 2019
MSC therapy is a promising research area for SCI due to their immunomodulating and neuroprotective factors supporting neuron survival and axonal growth without significant side effects. Clinical trial...
KEY FINDING: MSCs from bone marrow (BM-MSCs), umbilical cord (UC-MSCs), and adipose tissue (AD-MSCs) each have different characteristics regarding availability, invasiveness of collection, proliferation, secretome, survival after grafting, immunogenicity, anti-inflammatory effect, glial scar reduction, and axonal regrowth support.
Stem Cell Reports, 2019 • July 9, 2019
Neural progenitor cells (NPCs) transplanted into sites of spinal cord injury (SCI) extend large numbers of axons into the caudal host spinal cord. The majority of caudally projecting graft neurons (53...
KEY FINDING: The majority (53%) of caudally projecting graft neurons were located within the caudal one-third of the graft.
npj Regenerative Medicine, 2019 • May 3, 2019
The study investigated the therapeutic effect of combining cell transplantation with locomotor training (TMT) in rats with brain injury. Results showed that TMT promoted neurite extensions from grafte...
KEY FINDING: Locomotor training promoted neurite extensions from the grafted cells, with extensions reaching the spinal cord in the TMT(+) group but limited to the internal capsule in the TMT(−) group.