Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,881-1,890 of 2,298 results
Frontiers in Neurology, 2019 • April 2, 2019
The study establishes an MRI protocol in mice to monitor the regeneration of small nerves without contrast agents, focusing on the facial nerve. MRI scans revealed nerve hyperintensity after injury, w...
KEY FINDING: Nerve injury caused hyperintense signal in T2-weighted images, and an increase in nerve size of the proximal and distal nerve stumps were observed.
Scientific Reports, 2019 • April 1, 2019
This study introduces a chitosan-based hydrogel as a carrier for mesenchymal stem cells (MSCs) in treating spinal cord injuries (SCI). In vitro experiments demonstrated the hydrogel's biocompatibility...
KEY FINDING: Chitosan hydrogel supports MSC viability and function in vitro, allowing the cells to release therapeutic factors.
Stem Cell Reports, 2019 • May 14, 2019
Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. NPCs transplanted following SCI differentiate mainly into oligo...
KEY FINDING: NPCs transplanted following SCI differentiate mainly into oligodendrocytes and enhance myelination.
Front. Cell. Neurosci., 2019 • April 12, 2019
This study investigates the electrophysiological properties of adult zebrafish oligodendrocyte progenitor cells (OPCs) to understand their role in spinal cord regeneration. The research demonstrates t...
KEY FINDING: Adult zebrafish OPCs are electrically active and express functional voltage-gated K+ and Na+ channels.
Glia, 2019 • July 1, 2019
This study investigates the impact of aging on the ability of mesenchymal stem cells (MSCs) to promote oligodendrocyte generation and remyelination, processes crucial for treating demyelinating diseas...
KEY FINDING: MSCs derived from aged rats have a reduced capacity to induce oligodendrocyte differentiation of adult CNS stem/progenitor cells.
Scientific Reports, 2019 • May 7, 2019
This study investigates the role of epigenetic mechanisms, specifically histone deacetylases (HDACs), in axolotl tail regeneration using a chemical genetic screen. The screen identified several HDAC i...
KEY FINDING: A chemical screen identified 55 chemicals that inhibited axolotl tail regeneration, with histone deacetylase inhibitors (HDACi) being highly represented.
Molecular Neurobiology, 2019 • May 2, 2019
This study demonstrates that PEDF is an important mediator of DC axon regeneration in the adult mammalian system. PEDF is neuroprotective and promotes significant DRGN neurite outgrowth, exhibiting bo...
KEY FINDING: PEDF expression is upregulated in DRGN in vivo in regenerating models (SN, pSN + DC) of spinal cord injury.
Cells, 2019 • April 30, 2019
The study investigated the transcriptome-wide responses of Il-1β-primed rat Achilles tendon cell-derived 3D tendon-like constructs to high-energy PEMF treatment. RNASeq analysis revealed various biolo...
KEY FINDING: PEMF exposure of Il-1β-treated 3D tendon-like constructs resulted in a change in the expression pattern of approximately 5400 genes.
Stem Cell Reports, 2019 • May 2, 2019
The study investigates the cues that govern the maintenance versus differentiation of human medial ganglionic eminence (MGE) progenitors and explores methods for their large-scale expansion. It identi...
KEY FINDING: WNT/CTNNB1 signaling is essential for maintaining human MGE progenitors in an undifferentiated state.
Adv. Sci., 2019 • February 27, 2019
Here, we introduce a biomimicking aligned fiber platform which allows the delivery of miRs both in vitro and in vivo in a sustained and nonviral manner. The easy incorporation of different miRs into t...
KEY FINDING: Enhanced gene-silencing is achieved in neurons as compared to conventional bolus delivery (p < 0.05).