Stem Cell Reports, 2019 · DOI: https://doi.org/10.1016/j.stemcr.2019.03.013 · Published: May 14, 2019
This study explores how neural progenitor cells (NPCs) react when transplanted into spinal cord injuries (SCI). The researchers looked at how these cells change, what genes they turn on or off, how they affect inflammation, and whether they help with recovery. The study found that NPCs mainly become oligodendrocytes, which help to create myelin, a protective layer around nerve fibers. They also found that NPCs can change the activity of genes related to nerve cell communication and energy production. The researchers also discovered that NPCs can reduce inflammation in the injured spinal cord and are essential for improving the ability of the animals to move their hind limbs after a spinal cord injury.
NPCs can be a potential therapeutic strategy for SCI due to their ability to differentiate into oligodendrocytes and enhance myelination.
NPCs can suppress pro-inflammatory responses, suggesting a role in modulating the immune environment after SCI.
NPC transplantation can lead to enhanced recovery in hindlimb locomotor function, improving coordination and stepping patterns.