Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,871-1,880 of 2,298 results
Frontiers in Neuroscience, 2019 • February 21, 2019
This review discusses the current understanding of adult neurogenesis in mammalian brains, highlighting the differences between rodents, primates, and humans. It emphasizes the limitations of endogeno...
KEY FINDING: Adult neurogenesis is limited in humans compared to rodents, which impacts the brain's ability to self-repair.
BMC Neuroscience, 2019 • March 5, 2019
This study investigates the effect of lesion proximity on the regenerative response of long descending propriospinal (LDPT) neurons after spinal transection injury, comparing their response to that of...
KEY FINDING: Axonal injury closer to LDPT neuron cell bodies resulted in a different gene expression response compared to injury further away. This response was less robust than that observed in TPS neurons after proximal axotomy.
Molecular Neurobiology, 2019 • March 28, 2019
The study investigated the contribution of the BMP4/Smad1 pathway in promoting long-tract DRGN axon regeneration after DC injury in a rat model that cavitates. BMP4 and Smad1 mRNA and protein were hig...
KEY FINDING: BMP4 peptide promoted significant DRGN survival and disinhibited neurite outgrowth in vitro.
F1000Research, 2019 • March 20, 2019
This review highlights recent advances in applying multi-layer omics, new sophisticated bioinformatics tools, and cutting-edge imaging techniques to the study of axon regeneration and rebuilding of in...
KEY FINDING: Epigenomic screens identified Tet methylcytosine dioxygenase 3 (Tet3) as a critical regulator of axon growth and regeneration. After peripheral nerve lesion (PNL), Tet3 is upregulated along with the epigenetic mark 5-hydroxymethylcytosine (5hmC) in DRG neurons, reversing DNA methylation.
Semin Cell Dev Biol, 2020 • January 1, 2020
This review explores the role of epigenetic regulation in neuronal regeneration, focusing on the neural retina, inner ear, and spinal cord. The review highlights the importance of DNA accessibility, h...
KEY FINDING: Changes in DNA accessibility, histone acetylation, and DNA methylation are key epigenetic elements in neuronal regeneration.
Cell Death & Differentiation, 2019 • April 5, 2019
The study examined the impact of Zika virus (ZIKV) on human neural progenitor cells (NPCs) derived from different brain regions, finding that ZIKV infects these cells similarly, leading to growth arre...
KEY FINDING: ZIKV efficiently infects human NPCs from various brain regions (forebrain dorsal, forebrain ventral, hindbrain, and spinal cord) derived from human embryonic stem cells.
Neural Regen Res, 2019 • August 1, 2019
The review discusses the role and prospects of regenerative biomaterials in repairing spinal cord injuries (SCI). It highlights how biomaterials can address axonal junction defects and inhibitory envi...
KEY FINDING: Natural materials like collagen, chitosan, and hyaluronic acid offer good biocompatibility and biological functionality in SCI repair.
Exp Neurol, 2019 • August 1, 2019
In vivo imaging in the mouse spinal cord reveals that axonal branches markedly impact the degenerative and regenerative responses to injury. Neurons may choose either a self-preservative or a more dyn...
KEY FINDING: Axon injury relative to a branch point significantly impacts the degenerative and regenerative response.
eNeuro, 2019 • March 28, 2019
The study presents a novel transgenic mouse model, ATF3-CreERT2, for selective genetic editing of injured neurons. The ATF3-CreERT2 line facilitates recombination specifically in axotomized neurons, e...
KEY FINDING: The ATF3-CreERT2 mouse line allows for selective genetic editing of injured neurons after peripheral nerve injury (PNI) and spinal cord injury.
Cell Death & Disease, 2019 • April 3, 2019
This study demonstrates for the first time that NSC-derived sEVs can suppress neuronal apoptosis, microglia activation, and neuroinflammation, thereby promoting functional recovery in SCI model rats. Th...
KEY FINDING: NSC-sEVs can significantly reduce the extent of SCI, improve functional recovery, and reduce neuronal apoptosis, microglia activation, and neuroinflammation in rats.