Scientific Reports, 2019 · DOI: 10.1038/s41598-019-42848-w · Published: April 1, 2019
This study explores a new method for treating spinal cord injuries (SCI) by combining stem cells with a special material called a chitosan-based hydrogel. The hydrogel acts as a carrier for mesenchymal stem cells (MSCs), which release substances that help the spinal cord regenerate, reduce scarring, and prevent cell death at the injury site. The injectable hydrogel is designed to solidify at body temperature, ensuring the MSCs stay in place and continue to release their beneficial substances, promoting healing of the injured spinal cord.
The chitosan-based hydrogel can be used as an injectable carrier for stem cells to promote tissue regeneration and reduce inflammation in spinal cord injuries.
The hydrogel enhances the survival and retention of transplanted stem cells at the injury site, potentially improving the efficacy of cell-based therapies.
The hydrogel supports the paracrine activity of MSCs, facilitating the release of therapeutic factors that promote neuroprotection and neuroregeneration.