Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,861-1,870 of 2,298 results
J Tissue Eng Regen Med, 2019 • May 1, 2019
This study investigates a combinatorial tissue engineering approach for spinal cord injury repair, utilizing a biodegradable hydrogel scaffold, Schwann cells, and rapamycin-releasing microspheres. The...
KEY FINDING: Rapamycin, delivered locally from implanted scaffolds, reduces fibrosis and promotes functional neurologic recovery after spinal cord injury.
Front. Cell. Neurosci., 2019 • February 12, 2019
This study investigates the potential of human iPSC-derived neural progenitor cells (hNPCs) to enhance axon regeneration in the corticospinal tract (CST) by increasing the expression of α9 integrin. T...
KEY FINDING: Increasing α9 integrin expression in human iPSC-derived NPCs enhances neurite outgrowth in vitro, suggesting a functional role for α9 integrin in promoting axon growth.
Cell Rep, 2019 • February 26, 2019
Neural progenitor cell grafts form new relays across sites of spinal cord injury (SCI). Host corticospinal motor axons regenerating into neural progenitor grafts innervate appropriate pre-motor intern...
KEY FINDING: Spinal neural progenitor grafts adopt diverse spinal motor and sensory interneuronal fates, representing most neuronal subtypes of the intact spinal cord.
Scientific Reports, 2019 • February 28, 2019
This study introduces a novel two-component matrix, SPRPix, composed of recombinant spidroins and platelet-rich plasma (PRP), designed to enhance the growth and differentiation of human neural precurs...
KEY FINDING: The SPRPix matrix, combining recombinant spidroins and PRP, significantly enhanced drNPC proliferation and neuronal differentiation.
International Journal of Molecular Sciences, 2019 • February 28, 2019
This review summarizes the application of hepatocyte growth factor (HGF) for acute spinal cord injury (SCI), tracing the research journey from basic studies to human clinical trials. Preclinical studi...
KEY FINDING: Exogenous HGF administration during the acute phase of SCI reduces astrocyte activation, decreasing glial scar formation and exerting anti-inflammatory effects.
Cellular & Molecular Immunology, 2019 • March 15, 2019
Neuroinflammation, a hallmark of neurological disorders, can be both detrimental and beneficial to the central nervous system (CNS). While excessive inflammation can cause injury and death to neural e...
KEY FINDING: Neuroinflammation promotes neurogenesis by influencing the formation of new neurons, with T lymphocytes playing a role in learning-induced hippocampal neurogenesis.
PLoS ONE, 2019 • March 6, 2019
This study compares three methods for harvesting olfactory ensheathing cells (OECs) from the olfactory mucosa in dogs: rhinotomy, keyhole approach, and rhinoscopy. All three methods appear safe and pr...
KEY FINDING: The keyhole approach and rhinoscopy yielded similar proportions and populations of p75-positive cells, presumed to be olfactory ensheathing cells.
J Korean Neurosurg Soc, 2019 • March 1, 2019
This study aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI. Transplantation...
KEY FINDING: rPI-SCs display MSC characteristics and express neural and glial cell markers, including BDNF, GFAP, fibronectin, MAP2a,b, β3-tubulin, and nestin, as well as anti-inflammatory prostaglandin E2 receptor, EP3.
Communications Biology, 2019 • March 4, 2019
This study investigates the molecular mechanisms underlying the pro-regenerative glial cell response in axolotls after spinal cord injury, focusing on the roles of AP-1 transcription factors and miR-2...
KEY FINDING: Axolotl glial cells upregulate a non-canonical AP-1 complex, AP-1cFos/JunB, after spinal cord injury, unlike mammals where AP-1cFos/cJun is upregulated and promotes glial scar formation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019 • January 16, 2019
This study investigated the axolotl's ability to regenerate from a clinically relevant blunt spinal cord injury. Axolotls were subjected to a contusion SCI, and their regeneration was assessed using M...
KEY FINDING: Axolotls are capable of morphologically regenerating the spinal cord following a contusion trauma.