Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,851-1,860 of 2,298 results
Neurospine, 2019 • December 1, 2019
Spinal cord injury (SCI) is a devastating condition with limited regenerative capacity, leading to lifelong disability. Current treatments primarily focus on neurorehabilitation and managing complicat...
KEY FINDING: aFGF has shown promise for neural regeneration in multiple trials, including human and animal experiments, warranting further investigation as a neurotrophic factor.
International Journal of Molecular Sciences, 2019 • January 21, 2019
This review examines the behavior of transplanted neural stem cells (NSCs) in different injury models within the central nervous system (CNS). It compiles and compares various transplantation protocol...
KEY FINDING: In healthy CNS tissue, region-specific cues dominate cell fate decisions of transplanted NSCs.
PLoS ONE, 2019 • January 30, 2019
This study investigates the resilience of spinal cord regeneration in lampreys after a second spinal transection (re-transection). The findings indicate that lampreys regenerate just as robustly after...
KEY FINDING: Lampreys exhibit normal functional recovery of swimming after two successive spinal cord transections.
International Journal of Nanomedicine, 2019 • January 1, 2019
This study investigates the efficacy of a HAMC-KAFAK/BDNF hydrogel in promoting nerve regeneration in rats with spinal cord injury. The hydrogel is designed to provide sustained release of an anti-inf...
KEY FINDING: The HAMC-KAFAK/BDNF hydrogel demonstrates minimal swelling and sustained release of KAFAK and BDNF, suggesting its suitability for localized drug delivery.
Neural Regen Res, 2019 • June 1, 2019
This study investigated the effect of combining four different strategies (INDP, DPY, FG, and MSCs) on the behavioral and morphological recovery of rats with acute SCI. The results showed that animals...
KEY FINDING: The combination therapy (DPY+ INDP + FG + MSCs) was the best strategy to promote motor and sensibility recovery in rats with acute spinal cord injury.
Neural Regeneration Research, 2019 • June 1, 2019
This study investigates the effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha (HIF-1α) delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats. T...
KEY FINDING: Delivery of HIF-1α overexpression lentiviral vectors, especially when mediated by pluronic F-127 hydrogel, effectively promotes spinal root regeneration after brachial plexus avulsion.
Front. Cell. Neurosci., 2019 • February 4, 2019
This study demonstrates that a conditioning sciatic nerve lesion induces a pro-regenerative state in primary sensory neurons of both lumbar and remote cervical DRG. The pro-regenerative state is chara...
KEY FINDING: A unilateral sciatic nerve injury leads to a bilateral increase in growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein levels in both lumbar and cervical DRG neurons.
Curr Top Dev Biol, 2019 • January 1, 2019
The dorsal-ventral axis of the spinal cord is crucial for segregating neurons according to function, with motor neurons in the ventral horn and sensory interneurons in the dorsal horn. Ventral pattern...
KEY FINDING: The ventral spinal cord is patterned by Shh, which acts as a morphogen in a concentration-dependent manner.
Frontiers in Physiology, 2019 • February 8, 2019
This review discusses the biophysical, biochemical, and epigenetic processes involved in regenerative healing in amphibians, particularly tail and limb regeneration in Xenopus. The review highlights t...
KEY FINDING: Reactive oxygen species (ROS) signaling is rapidly activated after injury and is required for tail regeneration. Inhibition of ROS prevents full tail regeneration and affects the activation of Wnt signaling pathways.
The Journal of Neuroscience, 2019 • April 24, 2019
After brain or spinal cord trauma, interaction of Nogo-A with neuronal NgR1 limits regenerative axonal sprouting and functional recovery. The Nogo-A-induced association of NgR1 with CRMP2 requires Ple...
KEY FINDING: Nogo-A induces the association of NgR1 with CRMP2, and this requires PlexinA2 as a coreceptor.