Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury

This study investigates the potential of stem cells derived from pancreatic islets (rPI-SCs) to improve recovery after spinal cord injury (SCI) in rats. The researchers transplanted rPI-SCs into injured spinal cords and assessed motor function and inflammation levels. The study found that rPI-SCs displayed mesenchymal stem cell characteristics and expressed neural markers. Transplantation of these cells led to improved motor recovery and reduced inflammation at the injury site. These findings suggest that rPI-SCs could be a promising therapeutic strategy for enhancing functional recovery and reducing inflammation following spinal cord trauma.

• 1
  rPI-SCs display MSC characteristics and express neural and glial cell markers, including BDNF, GFAP, fibronectin, MAP2a,b, β3-tubulin, and nestin, as well as anti-inflammatory prostaglandin E2 receptor, EP3.
• 2
  BBB scores showed significant motor recovery in the group that received rPI-SC transplantation.
• 3
  Decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were observed in the rPI-SC transplantation group.