Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,801-1,810 of 2,298 results
Genomics, 2019 • December 1, 2019
This study compares the initial limb regeneration transcriptional response among ambystomatid salamanders using microarray and RNA-Seq. It identifies 405 non-redundant genes commonly and differently e...
KEY FINDING: Identified 405 non-redundant genes that were commonly, differentially expressed 24 h post amputation across three Ambystoma species.
Journal of Experimental Pharmacology, 2018 • January 1, 2018
This review highlights the use of polyethylene glycol (PEG), a synthetic material known for its capacity to immediately repair physical damage and reduce local glial scar formation, and its applicatio...
KEY FINDING: PEG, as a fusogen, can repair compromised neuronal membranes in SCI, potentially by dehydrating the cell membrane or reducing surface tension.
PNAS, 2018 • August 13, 2018
This study investigates the divergent tail regeneration outcomes in lizards and salamanders, focusing on the role of neural stem cells (NSCs) in the spinal cords of regenerated tails. The research rev...
KEY FINDING: Salamander NSCs can differentiate into multiple neural lineages, while lizard NSCs are restricted and primarily form astrocytes.
Neural Regeneration Research, 2018 • August 1, 2018
The brain's ability to adapt and change, known as neuroplasticity, is crucial for maintaining its biological renaissance. Adult neurogenesis, the generation of new neurons in the adult brain, is a key...
KEY FINDING: Adult neurogenesis occurs not only in the hippocampus and SVZ but also in other brain regions like the cortex, amygdala, hypothalamus, and striatum, which are associated with the limbic system and basal ganglia.
Neural Regen Res, 2018 • August 1, 2018
The perspective piece emphasizes the complex and dynamic nature of the glial scar following spinal cord injury (SCI), moving beyond the outdated view of it being a simple barrier composed only of astr...
KEY FINDING: The glial scar is a multicellular structure comprising astrocytes, oligodendrocyte progenitor cells, microglia, macrophages, and fibroblasts/pericytes, all responding to the inflammatory environment after SCI.
Biophysical Journal, 2018 • September 4, 2018
This study uses Brillouin microscopy to map the mechanical properties of spinal cord tissue in living zebrafish larvae during development and after spinal cord injury, providing a non-destructive metho...
KEY FINDING: The Brillouin shift within the spinal cord remained comparable during development, indicating stable mechanical properties.
PNAS, 2018 • August 20, 2018
The study reveals that advillin, a sensory neuron-specific protein, plays a critical role in axonal regeneration of IB4+ sensory neurons and facilitates recovery from peripheral neuropathy and neuropa...
KEY FINDING: Advillin expression is restricted to isolectin B4-positive (IB4+) neurons in the adult dorsal root ganglia (DRG).
Scientific Reports, 2018 • August 10, 2018
The study demonstrates that forced expression of KLF6 promotes axon regeneration in corticospinal tract neurons after spinal cord injury. RNA sequencing identified genes whose expression changed upon ...
KEY FINDING: Forced expression of KLF6 promotes axon regeneration by corticospinal tract neurons in the injured spinal cord.
Neural Regeneration Research, 2018 • October 1, 2018
Spinal cord injuries are debilitating conditions lacking effective cures. Stem cell therapy, particularly using iPSCs, offers hope for restoring lost neural function. Bioscaffolds can protect and guid...
KEY FINDING: iPSCs can differentiate into various cell types, including neurons and supportive cells, aiding in myelination, axon regeneration, and synaptic connection growth at the injury site.
Neural Regen Res, 2018 • October 1, 2018
This study investigated the effect of combined VEGF and PDGF treatment on olfactory neuron regeneration and glial scar formation after unilateral bulbectomy in neonatal mice. The results showed that t...
KEY FINDING: The growth factor treatment significantly increased the number of immature neurons at 5 and 7 days post-injury.