Combined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice

The olfactory system, responsible for our sense of smell, can regenerate throughout life. This study explores whether two growth factors, VEGF and PDGF, can improve the regeneration of olfactory neurons after injury in mice. The researchers induced olfactory neuron degeneration by removing one olfactory bulb (unilateral bulbectomy) in mice. One group received combined VEGF/PDGF, while the control group received saline. The study found that the growth factor treatment increased the number of new neurons, reduced glial scar formation, and enhanced axon regeneration in the injured olfactory system of mice.

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  The growth factor treatment significantly increased the number of immature neurons at 5 and 7 days post-injury.
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  The treatment also increased the number of mature olfactory neurons at 10 and 14 days post-bulbectomy.
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  Regenerating axons extended over a larger volume in the operated cavity in the treatment group compared to the control group at 14 days post-bulbectomy.