Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,791-1,800 of 2,298 results
Scientific Reports, 2018 • July 19, 2018
This study investigates the effects of non-functionalized soft calcium alginate hydrogel implants on spinal cord injury in rats, using label-free multiphoton microscopy for detailed tissue characteriz...
KEY FINDING: Alginate hydrogel implantation led to better hindlimb function recovery in rats with spinal cord injuries compared to untreated controls, suggesting that the hydrogel has a positive effect on functional outcomes.
Neural Regeneration Research, 2018 • July 1, 2018
This study fabricated a partition-type tubular scaffold loaded with PDGF-releasing microspheres for spinal cord repair. The scaffold was designed to mimic the anatomical features of the spinal cord an...
KEY FINDING: Pre-freezing the chitosan scaffold at −20°C for 2 hours significantly increased the yield of partition-type tubular scaffolds.
Neural Regeneration Research, 2018 • July 1, 2018
This study evaluated the effect of Governor Vessel electroacupuncture (EA) combined with early or delayed decompression on acute upper cervical spinal cord injury (SCI) in rats. The results indicated ...
KEY FINDING: Hind limb motor function recovery was superior after decompression for 12 and 48 hours combined with electroacupuncture compared to decompression alone.
Biol Blood Marrow Transplant, 2018 • July 1, 2018
The study highlights significant variability in MSC manufacturing protocols across European centers, impacting the consistency of clinical products. Key variations were identified in tissue sources, c...
KEY FINDING: Most centers use bone marrow as the source for MSCs, but there's a shift from fetal bovine serum to human platelet lysate as a medium supplement.
Nat Cell Biol, 2018 • August 1, 2018
This study reveals a previously unappreciated function of FAPs as a source of pro-atrophic and pro-fibrotic signals in denervated muscles, particularly due to the aberrant activation of IL6-STAT3 sign...
KEY FINDING: Denervation leads to the accumulation of FAPs in skeletal muscles, without a corresponding increase in macrophages or muscle stem cells.
Acta Biomater, 2018 • September 15, 2018
The study addresses the challenge of repairing critical nerve injuries with long gaps, where traditional methods like autografts have limitations. It explores the potential of growth factors, specific...
KEY FINDING: Pleiotrophin (PTN) and glial-derived neurotrophic factor (GDNF) have a synergistic effect on axonal regeneration in vitro, promoting both sensory and motor neuron growth.
Nature Communications, 2018 • August 2, 2018
This study investigated the role of oligodendrocyte remyelination in locomotor recovery after spinal cord injury (SCI) by selectively ablating it in transgenic mice. The researchers found that while M...
KEY FINDING: MYRF expression in PDGFRα-positive cell-derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI.
Mol Cell Neurosci, 2018 • October 1, 2018
This study investigates the genomic locations bound by Jun in DRG neurons following a peripheral axotomy, observing that the majority of Jun’s injury-responsive binding sites are on putative enhancer ...
KEY FINDING: The majority of Jun's injury-responsive changes in DNA binding occur at putative enhancer elements, not proximal to transcription start sites.
STEM CELLS TRANSLATIONAL MEDICINE, 2018 • August 7, 2018
The purpose of this study was to first generate oligodendrogenic-NPCs (oNPCs) efficiently from established human NPC lines, including drNPCs and iPSCs, using our novel method. We next assessed the effica...
KEY FINDING: Transplanted cells showed significant migration along the rostro-caudal axis and proportionally greater differentiation into oligodendrocytes.
Nature Communications, 2018 • August 9, 2018
This work is based on the development of a biodegradable hybrid inorganic nanoscaffold and its utilization for the enhanced transplantation of stem cells into SCI sites. Our demonstrated nanoscaffold ...
KEY FINDING: The 3D-MnO2 nanoscaffolds can improve neuronal differentiation and neurite outgrowth, through the enhanced laminin binding and focal adhesion-related pathways.