Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,811-1,820 of 2,298 results
Nature Communications, 2018 • August 23, 2018
The study demonstrates the successful derivation and characterization of human SC-NES cells as candidates for cell-based therapy in SCI treatment, showing they are highly expandable and retain neuroge...
KEY FINDING: Human spinal cord-derived neuroepithelial stem cells (SC-NES) robustly engraft into lesioned immunodeficient mice.
Exp Neurol, 2018 • December 1, 2018
The study evaluated the effects of intravenous administration of human bone marrow CD34+ (hBM34+) cells on structural and functional capillary repair in the spinal cords of symptomatic G93A SOD1 mice....
KEY FINDING: The high dose of hBM34+ cells significantly restored capillary ultrastructure in the spinal cords of ALS mice. Electron microscopy showed improvements in the morphology of endothelial cells, pericytes, and basement membranes.
Journal of Anatomy, 2018 • September 7, 2018
This study investigates the potential of enteric neural stem cells (ENSCs) as a stem cell source for spinal cord injury (SCI) repair using the chick embryo model. The study demonstrates that ENSCs can...
KEY FINDING: ENSCs co-cultured with spinal cord cells formed close connections, indicating potential for integration.
Stem Cell Reports, 2018 • September 6, 2018
Axonal regeneration after spinal cord injury (SCI) can be enhanced by activation of the intrinsic neuronal growth state and, separately, by placement of growth-enabling neural progenitor cell (NPC) gr...
KEY FINDING: Sensory conditioning lesions can activate the intrinsic host neuronal growth state and enhance host axonal regeneration into NPC grafts, resulting in a 9.6-fold increase in sensory axon regeneration into the NPC graft.
Theranostics, 2018 • August 7, 2018
This study introduces a novel multi-drug delivery system for spinal cord injury (SCI) repair, utilizing scar-homing liposomes loaded with docetaxel (DTX) and growth factors (GFs) embedded in a thermos...
KEY FINDING: The scar-homing liposomes (CAQK-LIPs) specifically bind to the lesion site after SCI, enabling targeted drug delivery.
Journal of Visualized Experiments, 2018 • September 1, 2018
The study presents a detailed protocol for in vivo electroporation of adult mouse dorsal root ganglion (DRG) to manipulate gene expression in sensory neurons. This approach enables the investigation o...
KEY FINDING: The study demonstrates a detailed protocol for in vivo electroporation of adult mouse DRG to manipulate gene expression in sensory neurons.
The Journal of Neuroscience, 2018 • October 24, 2018
This study identifies a previously unrecognized population of PNS glia that can participate in the regeneration of new myelin sheaths following CNS demyelination. The findings show that Foxj1 is also ...
KEY FINDING: A subpopulation of nonmyelinating Schwann cells identified by Foxj1 expression contributes to CNS SC remyelination, as well as remyelination in the PNS.
Mol Neurobiol, 2019 • June 1, 2019
This study aimed to identify pharmacological enhancers of axon regeneration using an in vitro cortical scrape assay. A compound library was screened, and diltiazem, verapamil, and bromopride were foun...
KEY FINDING: Diltiazem, verapamil, and bromopride were identified as compounds that facilitate axon regeneration in rat cortical cultures in the presence of CSPGs.
Chinese Journal of Reparative and Reconstructive Surgery, 2018 • August 1, 2018
The review provides a historical overview of glial scar research in the context of spinal cord injury repair. It summarizes the conflicting views on the role of glial scars in nerve regeneration and f...
KEY FINDING: The traditional view of glial scars as physical barriers to nerve regeneration is being challenged.
BMC Genomics, 2018 • September 13, 2018
This study presents the first de novo reference transcriptome of limb regeneration for Bolitoglossa ramosi, a plethodontid salamander. The study identified differentially expressed genes during limb r...
KEY FINDING: A de novo reference transcriptome for B. ramosi was generated, containing 433,809 transcripts and functional annotation for 142,926 non-redundant transcripts.