大鼠坐骨神经损伤后 Spastin 表达变化的实验研究 (Experimental study on Spastin expression changes after sciatic nerve injury in rats)

This study investigates the role of Spastin, a microtubule-remodeling protein, in nerve regeneration after sciatic nerve injury in rats. The experiment involved creating a sciatic nerve compression injury model in rats and observing changes in Spastin expression during the regeneration process. The findings suggest that Spastin plays a role in nerve regeneration after injury, potentially by influencing microtubule dynamics within nerve cells.

• 1
  Spastin mRNA and protein expression levels decreased initially after sciatic nerve injury, reaching a minimum at 7 days, and then gradually increased to initial levels by 28 days.
• 2
  The expression levels of Spastin mRNA and protein at 3, 7, and 14 days post-injury were significantly lower than those in the control group.
• 3
  Electron microscopy revealed myelin damage in the sciatic nerve at 1, 3, and 7 days post-injury, followed by Schwann cell proliferation at 14 days, and the presence of myelinated nerve fibers resembling normal morphology at 28 days.