Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,711-1,720 of 2,298 results
Journal of Medical Case Reports, 2017 • November 27, 2017
This case report details the successful use of human umbilical cord mesenchymal stem cells (hUC-MSCs) to treat a 62-year-old woman with chronic renal failure and thoracic spinal cord entrapment. The p...
KEY FINDING: After hUC-MSC treatment, the patient could move her toes three weeks after the first intrathecal and intravenous implantation.
Cell Tissue Res, 2018 • January 1, 2018
Neural stem cells (NSCs) are the stem cells of the nervous system. During development they give rise to the entire nervous system. Because NSCs are regulated by both intrinsic genetic and epigenetic p...
KEY FINDING: During development, the central nervous system (CNS) is generated from a small number of neural stem cells (NSCs) lining the neural tube.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017 • April 28, 2017
This study investigates the effect of transplanting activated microglial cells into injured spinal cords of adult rats. The experiment involved inducing spinal cord injuries in rats and then injecting...
KEY FINDING: Rats in the microglia-treated group (M) demonstrated significant improvement in locomotor performance compared to the control group (C).
Data in Brief, 2018 • November 4, 2017
The study investigates spinal cord regeneration in larval zebrafish after mechanical transection, focusing on the restoration of anatomical continuity. Spreading of fluorescently-labelled dextran alon...
KEY FINDING: Anatomical continuity is rapidly restored after complete spinal cord transection in larval zebrafish.
Front. Neural Circuits, 2017 • November 23, 2017
This review highlights the contributions of Xenopus laevis as a model organism for studying spinal cord formation, development, function, and regeneration. The advantages of using Xenopus include its ...
KEY FINDING: Xenopus laevis has been instrumental in identifying factors involved in neural induction, such as Noggin, Chordin, and Follistatin, all inhibitors of the Bone Morphogenetic Protein (BMP) pathway and Fibroblast Growth Factor (FGF).
PLoS ONE, 2017 • December 11, 2017
This study investigated the transplantation of canine olfactory ensheathing cells (OECs) genetically modified to produce chondroitinase ABC (ChABC) into a rodent model of spinal cord injury (SCI). The...
KEY FINDING: Genetically modified canine OECs survived transplantation into rat spinal cord lesions for at least four weeks.
Scientific Reports, 2017 • December 15, 2017
This study introduces a novel biodegradable gelatin-BVSM conduit for peripheral nerve repair, addressing limitations of autologous and allogenic nerve grafts. The gelatin-BVSM conduit demonstrates pro...
KEY FINDING: The gelatin-BVSM conduits exhibited suitable mechanical strength, were hydrophilic, and non-cytotoxic to Schwann cells.
Iranian Journal of Basic Medical Sciences, 2017 • December 1, 2017
This systematic review aimed to determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish by searching PubMed and Scopus databases. The review found that Wnt/ß-catenin s...
KEY FINDING: Wnt/ß-catenin signaling promotes neurogenesis and axonal regrowth after SCI in zebrafish.
Neurobiology of Disease, 2018 • March 1, 2018
This study demonstrates that one of the signaling cascades induced by RARβ activation in injured neurons is endogenous RA signaling in NG2+ cells and neurons at the injury site. The RA paracrine signa...
KEY FINDING: Neuronal RARβ activation induces endogenous RA signaling in NG2+ cells and neurons at the injury site after spinal cord injury.
The Journal of Neuroscience, 2018 • February 7, 2018
This study demonstrates that intraneural injection of ATP can elevate the regenerative state of DRG neurons and stimulate the growth of their central axons in injured spinal cord. ATP injection is als...
KEY FINDING: A single injection of ATP into the sciatic nerve quadrupled the number of axons growing into a lesion epicenter in the spinal cord after a dorsal column transection.