Improvement of renal function after human umbilical cord mesenchymal stem cell treatment on chronic renal failure and thoracic spinal cord entrapment: a case report

This case report describes how stem cell treatment improved kidney function and spinal cord issues in a 62-year-old woman. The patient had chronic renal failure and thoracic spinal cord entrapment, leading to paraplegia. The patient received human umbilical cord mesenchymal stem cells (hUC-MSCs) via intrathecal and intravenous routes. After treatment, she regained some movement in her legs and her kidney function improved, indicated by decreased creatinine levels and the resumption of urination. The study suggests that hUC-MSC implantation can significantly improve spinal cord entrapment and kidney failure. However, the study emphasizes the importance of addressing the major histocompatibility in allogeneic implantation in future research.

• 1
  After hUC-MSC treatment, the patient could move her toes three weeks after the first intrathecal and intravenous implantation.
• 2
  The patient's creatinine level decreased from 11 mg/dl to 9 mg/dl three weeks after the first hUC-MSC treatment and eventually to 2 mg/dl after 8 months.
• 3
  After 8 months of hUC-MSC treatment, the patient could raise her legs and had normal urination, which had been absent for 2 years prior to treatment.