Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,721-1,730 of 2,298 results
PLoS ONE, 2018 • January 2, 2018
This study investigated the distribution and cellular targeting of intravenously infused MSCexos in rats with SCI. The MSCexos were detected in the contused regions of the spinal cord and the spleen. ...
KEY FINDING: IV delivered MSCexos traffic to contusive SCI sites but not uninjured spinal cord tissue.
npj Regenerative Medicine, 2016 • June 9, 2016
This study demonstrates a rapid and efficient method for gene knockout in axolotls using electroporation of CAS9 protein–gRNA complexes. The method allows for tissue-specific and temporally controlled...
KEY FINDING: Electroporation of CAS9 protein–gRNA complexes is more efficient than plasmid-based CRISPR systems for gene knockout.
J Neural Eng, 2018 • April 1, 2018
The three-component hydrogel presented here has the potential to provide cues to direct differentiation in vivo to encourage regeneration of the central nervous system. Transplantation of hydrogels op...
KEY FINDING: Our results demonstrate that we can achieve a significant increase in oligodendrocyte differentiation of NPCs compared to standard culture conditions using a three- component biomaterial composed of collagen, hyaluronic acid, and laminin that has mechanical properties matched to those of neonatal neural tissue.
Cell Journal, 2018 • April 1, 2018
The study investigates the potential of co-transplantation of human neurotrophic factor-secreting cells (NTF-SCs) and adipose-derived stem cells (hADSCs) to promote remyelination in a rat model of mul...
KEY FINDING: Histological studies showed some remyelination in cell transplantation groups compared to others, indicating that the transplanted cells had a positive impact on myelin repair.
Nature Communications, 2018 • January 26, 2018
This study investigates whether adult, injured host axons regenerating into neural progenitor cell (NPC) grafts form appropriate connections. Spinal cord NPCs were grafted into the injured adult rat s...
KEY FINDING: Spinal cord NPCs transplanted into the injured adult spinal cord can differentiate into multiple subtypes of neurons with distinct lineage identities.
International Journal of Molecular Sciences, 2018 • January 9, 2018
This study explores the combined therapeutic effects of epSPCi transplantation and FM19G11 administration in rats with severe SCI. The combined treatment showed improvements in locomotor tasks and his...
KEY FINDING: The combination of epSPCi and FM19G11 improves locomotor tasks compared to the control group, though not significantly better than individual treatments in BBB scores.
International Journal of Molecular Sciences, 2018 • January 9, 2018
This study investigated the effects of intraarticular administration of MSCs in a rat model of shoulder arthritis induced by MIA. The findings indicate that MSCs can inhibit central sensitization of p...
KEY FINDING: Intraarticular injection of MSCs decreased the expression of CGRP in the spinal dorsal horn, indicating a suppression of central sensitization of pain.
Neural Regeneration Research, 2017 • December 1, 2017
This study investigated the potential of methylprednisolone (MP), vitamin C (VC), and bone marrow mesenchymal stem cells (BMMSCs) to treat traumatic spinal cord injury (SCI) in rats. The results showe...
KEY FINDING: BMMSCs intervention better promoted recovery of nerve function of rats with SCI, mitigated nerve cell damage, and decreased expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes than MP and/or VC.
Front. Cell. Neurosci., 2017 • December 13, 2017
The study demonstrates that spinal cord cells from regenerative-stage Xenopus laevis larvae can be successfully transplanted into the injured spinal cords of non-regenerative froglets. These transplan...
KEY FINDING: Transplanted spinal cord cells from regenerative-stage larvae can survive up to 60 days in the injured spinal cord of non-regenerative froglets.
J Tissue Eng Regen Med, 2018 • January 2, 2018
This study investigates the potential of human embryonic stem cell-derived neural crest cells (hESC-NCCs) to promote peripheral nerve regeneration using artificial nerve grafts. The researchers succes...
KEY FINDING: Differentiated NCCs from hESCs exhibit typical morphology and protein expression signatures comparable to native neural crest cells.