Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 141-150 of 2,298 results
PLoS ONE, 2013 • May 27, 2013
The study provides a comparative analysis of prominin-1–positive progenitor cells across species, establishing a framework for further functional characterization in the context of regeneration. The r...
KEY FINDING: Prominin-1 expression is conserved in proliferative ventricular neurogenic cells across vertebrate species.
Iranian Biomedical Journal, 2013 • July 1, 2013
This study aimed to evaluate the potential of bone marrow-derived Schwann cells (SCs) to improve functional recovery in rats after spinal cord injury (SCI). Mesenchymal stem cells (MSCs) were differen...
KEY FINDING: Differentiated cells showed Schwann cell morphology and markers in vitro.
J Neuropathol Exp Neurol, 2013 • July 1, 2013
The study aimed to determine if brief electrical stimulation of transplanted embryonic ventral spinal cord cells could improve motoneuron survival, axon regeneration, muscle reinnervation, and functio...
KEY FINDING: Brief electrical stimulation at 1 Hz for 1 hour significantly increased the number of myelinated axons.
BMC Surgery, 2013 • June 24, 2013
This study aimed to compare the efficacy of peripheral nerve (PN) transplantation and ventral root re-implantation in restoring motor neuron function after brachial plexus injury in rats. The results ...
KEY FINDING: Re-implantation of ventral roots significantly increased the survival and regeneration of motoneurons compared to PN graft transplantation.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
This systematic review analyzes studies using biomaterials to promote neuronal regeneration after spinal cord injury (SCI) in rodents. The review focuses on multimodal interventions combining biodegra...
KEY FINDING: Biomaterial-based interventions resulted in modest functional improvement in rodent models of SCI.
Cerebral Cortex, 2014 • June 28, 2013
The study demonstrates that direct cortical delivery of the PKC inhibitor GÖ6976 promotes CST axonal regeneration and enhances forelimb functional recovery in rats with cervical spinal cord injuries. ...
KEY FINDING: Cortical delivery of GÖ6976 reduced injury-induced activation of conventional PKCα and PKCβ1 in CST neurons.
International Journal of Nanomedicine, 2013 • June 20, 2013
The study investigates the therapeutic potential of iron oxide nanoparticles (IONPs) and magnetic field (MF) exposure in rats with complete spinal cord injury (SCI). Locomotor and sensorimotor assessm...
KEY FINDING: IONP implantation combined with MF exposure significantly reduced functional deficits after spinal cord injury in rats.
The Journal of Neuroscience, 2013 • July 3, 2013
The study used a multistep screening approach to discover genes specifically contributing to the regeneration-promoting properties of OECs. Microarray screening and functional characterization identif...
KEY FINDING: Sixteen genes in OECs (ADAMTS1, BM385941, FZD1, GFRA1, LEPRE1, NCAM1, NID2, NRP1, MSLN, RND1, S100A9, SCARB2, SERPINI1, SERPINF1, TGFB2, and VAV1) significantly reduced outgrowth of cocultured DRG neurons.
PLoS ONE, 2013 • June 19, 2013
The study demonstrates that nestin-expressing cells in the sciatic nerve can differentiate into various cell types and contribute to nerve fiber growth in a 3D culture system. The research shows that ...
KEY FINDING: Nestin-expressing cells in the sciatic nerve have the ability to form spheres and differentiate into neurons, glia, keratinocytes, and smooth muscle cells in vitro.
PLoS ONE, 2013 • July 3, 2013
This study uses a genetic approach to understand the variation in tail regeneration among salamanders. A hybrid population of Ambystoma salamanders was studied to identify genetic and morphological fa...
KEY FINDING: Tail width at the amputation plane largely determines the rate of regenerative outgrowth in salamanders.