Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 151-160 of 2,298 results
Neurosci Bull, 2013 • August 1, 2013
The study investigated functional recovery and anatomical regeneration after spinal cord transection in rats at different developmental stages (PN1, PN7, PN14, and adult). Neonatal rats (PN1 and PN7) ...
KEY FINDING: Rats transected at PN1 and PN7 showed a significant level of stepping function after complete spinal cord transection, unlike PN14 and adult rats.
Neurosci Bull, 2013 • August 1, 2013
Successful axonal regeneration in the injured nervous system is a complex process that involves coordinated regulation of gene expression in the soma and cytoskeleton assembly at the growth cone. The ...
KEY FINDING: A large-scale RNAi-based genetic screen has identified dual leucine zipper-bearing kinase 1 (DLK-1) as a key regulator of axon regeneration
STEM CELLS TRANSLATIONAL MEDICINE, 2013 • August 9, 2013
The study investigates enhancing tissue regeneration using progenitor cell-based therapy, addressing the primary barrier of the hostile environment that progenitor cells encounter in clinical injury w...
KEY FINDING: Overexpression of Bcl-2 in hASCs decreases mediators of apoptosis in vitro and in vivo.
Anat Cell Biol, 2013 • June 12, 2013
This review discusses the potential of carbon nanotubes (CNTs) in treating central nervous system (CNS) injuries by supporting stem cell differentiation and tissue regeneration. CNTs' unique propertie...
KEY FINDING: CNTs' structure and dimensions resemble neuronal network elements, enabling better control over physiological activity and neuronal information processing.
Exp Eye Res, 2014 • June 1, 2014
This article reviews the mechanisms involved in neuronal regeneration in the adult zebrafish retina, focusing on the role of Müller glia. Retinal damage induces Müller glia to dedifferentiate and reen...
KEY FINDING: TNFα, a signaling molecule, is produced by dying retinal neurons and signals to Müller glia to initiate proliferation. Knockdown of TNFα expression significantly reduced Müller glial proliferation.
Exp Neurol, 2013 • October 1, 2013
This study examined the pre-clinical potential of NPCs derived from human induced pluripotent stem cells (hiPSCs) to repair chronic SCI. hiPSCs were differentiated into region-specific (i.e. caudal) N...
KEY FINDING: Caudalized hiPSC-NPCs can be successfully transplanted into an early chronic cervical SCI model and survive for up to two months post-transplant without risk of overgrowth or loss of function.
Cell Mol Neurobiol, 2013 • July 28, 2013
This study aimed to determine if Wnt signaling-activated olfactory ensheathing cells (wOECs) can promote synaptogenesis and neurite growth in vitro, comparing them to control OECs and Wnt-inhibited OE...
KEY FINDING: Wnt-activated OECs (wOECs CM) exhibited a stronger axonal growth-promoting effect than control OECs CM (cOECs CM).
Neurosci Bull, 2013 • August 1, 2013
This review provides an overview of different animal models used in spinal cord injury research, specifically focusing on axon regeneration. It discusses the pros and cons of each model, including con...
KEY FINDING: Rat models mimic human SCI pathology better due to the formation of cystic cavities, making them suitable for preclinical studies of cellular and pharmacological therapies.
Trends Genet, 2013 • November 1, 2013
Zebrafish are a key genetic model system for vertebrate regeneration research. Toolsets continue to evolve for studies of zebrafish appendage, heart, and neural regeneration. Regeneration concepts and...
KEY FINDING: Differentiated osteoblasts transiently downregulate the osteogenic program, or dedifferentiate, as they contribute to the blastema. After this, resident osteoblasts contribute only osteoblasts to new regenerated structures
PLoS ONE, 2013 • August 2, 2013
This study investigates the role of SnoN, a developmentally-regulated transcription factor, in promoting axonal regeneration after spinal cord injury. The research aims to address the limited growth c...
KEY FINDING: SnoN overexpression in adult DRG neurons significantly enhances neurite growth in vitro.