Iron oxide nanoparticles and magnetic field exposure promote functional recovery by attenuating free radical-induced damage in rats with spinal cord transection

This study explores using iron oxide nanoparticles (IONPs) and magnetic fields (MF) to help rats recover from spinal cord injuries. The researchers implanted IONPs at the injury site and exposed the rats to MF for five weeks. The results showed that rats treated with both IONPs and MF had better motor function and less tissue damage at the injury site. The IONPs seemed to help reduce oxidative stress, which can worsen spinal cord injuries. These findings suggest that IONPs and MF could potentially be a therapy for spinal cord injuries and other nerve problems caused by oxidative stress.

• 1
  IONP implantation combined with MF exposure significantly reduced functional deficits after spinal cord injury in rats.
• 2
  The combination of IONPs and MF exposure led to a reduction in lesion volume and an absence of collagenous scar tissue formation at the injury site.
• 3
  In vitro experiments demonstrated that IONPs exhibit free radical scavenging properties, reducing H2O2-mediated oxidative stress.