Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 131-140 of 2,298 results
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study demonstrates that blocking EphA4 activation with EphA4-Fc improves functional outcomes and promotes structural changes in a rat model of contusive spinal cord injury. The researchers found ...
KEY FINDING: EphA4-Fc treatment significantly improves locomotor function in rats after contusive spinal cord injury, as measured by the ledged tapered balance beam task and open-field testing.
Cell Death and Disease, 2013 • April 4, 2013
This study investigates the role of SHP-1, an intracellular protein tyrosine phosphatase, in axonal reorganization and functional recovery after brain injury. The researchers hypothesized that SHP-1 n...
KEY FINDING: SHP-1 expression and activity increase in the contralesional cortex (the side opposite the injury) after a unilateral motor cortex injury.
Neuroscience, 2013 • August 15, 2013
Reticulospinal (RS) neurons are critical for initiation of locomotor behavior, and following spinal cord injury (SCI) in the lamprey, the axons of these neurons regenerate and restore locomotor behavi...
KEY FINDING: Activation of cAMP pathways with forskolin or dbcAMP stimulated neurite outgrowth of RS neurons in culture in a PKA-dependent manner.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study meticulously characterized the phenotypic diversity and plasticity of hGRP prepared by a Good Manufacturing Practice (GMP) production standard for possible clinical application. The study f...
KEY FINDING: hGRP and hGRP-derived astrocytes showed excellent survival and expressed astrocyte markers after transplantation into a spinal cord lesion.
PLoS ONE, 2013 • April 24, 2013
This study compares the potential of OECs from the olfactory bulb (OB-OECs) and olfactory mucosa (OM-OECs) for spinal cord repair after severe SCI. The results demonstrate that transplantation of OECs...
KEY FINDING: Transplantation of OECs from OB or OM induces electrophysiological and functional recovery after spinal cord injury.
Trends Neurosci, 2013 • June 1, 2013
CNS regeneration inhibitors, including Nogo-A, OMgp, and CSPGs, have novel functions in regulating dendritic spine maturation, synapse stability, and synaptic plasticity in the naïve CNS. These inhibi...
KEY FINDING: CNS regeneration inhibitors like Nogo-A and CSPGs promote dendritic spine maturation and stability, influencing neuronal structure in a cell-autonomous manner.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013 • June 21, 2013
This study aimed to understand how HMGB1, a protein known to mediate inflammation in mammalian spinal cord injuries, functions in animals capable of spontaneous spinal cord regeneration, specifically ...
KEY FINDING: Gecko HMGB1 paralogs (gHMGB1a and gHMGB1b) exhibit differential responses to spinal cord trauma and inflammatory challenges, with gHMGB1b significantly upregulated in the injured cord.
PLoS ONE, 2013 • May 7, 2013
The study investigates the effects of a snake venom-derived fibrin sealant on functional recovery, neuronal survival, synaptic plasticity, and glial reaction after ventral root reimplantation. The res...
KEY FINDING: Root reimplantation with fibrin sealant enhances motor recovery and improves neuronal survival.
Iranian Red Crescent Medical Journal, 2013 • February 1, 2013
This study aimed to assess the therapeutic potential of cholinergic neuron-like cells (CNLs) derived from bone marrow stromal cells (BMSCs) in a rat model of spinal cord contusion. The results demonst...
KEY FINDING: Rats treated with CNLs showed a higher rate of improvement in motor function compared to those treated with BMSCs alone or the untreated group, as measured by the BBB test.
Int. J. Mol. Sci., 2013 • May 24, 2013
The study explores using magnetized olfactory ensheathing cells (OECs) for treating spinal cord injuries. OECs are modified with magnetic nanoparticles (MNPs) to enable controlled migration via magnet...
KEY FINDING: Magnetized OECs survive well without showing stress-related cellular responses.