Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,431-1,440 of 2,298 results
International Journal of Nanomedicine, 2025 • February 11, 2025
This review summarizes the current research status of the application of biomaterials to the SCI treatment, in recent years, to provide some comprehensive information and reference value for future ex...
KEY FINDING: Biomaterial scaffolds can be used for drug delivery, cell load, and tissue engineering to facilitate the repair of SCIs, while acting as a scaffold and microenvironment for tissue growth with reduced inflammatory responses.
Journal of Materials Science: Materials in Medicine, 2025 • January 10, 2025
This study investigated the therapeutic effects of plasma-synthesized polypyrrole/iodine (PPy/I) biopolymer in Rhesus monkeys with complete spinal cord transection (SCT), comparing an experimental gro...
KEY FINDING: Plasma-synthesized PPy/I reduced the levels of pro-inflammatory cytokines in the experimental NHP compared to the control NHP after spinal cord transection.
Materials Today Bio, 2025 • January 27, 2025
This study successfully fabricated 3D-printed Ga-MBG/TCP scaffolds with interconnected porous structures and controlled gallium ion release. In vitro experiments demonstrated that the Ga-MBG/TCP compo...
KEY FINDING: The 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis.
eLife, 2024 • February 24, 2025
This study developed an in vitro model of DRG neurons that recapitulates their in vivo development, pseudo-unipolarization, and establishment of polarity, serving as a valuable resource for understand...
KEY FINDING: DRG neurons in vitro undergo pseudo-unipolarization, replicating in vivo asymmetries and regenerative capacity.
Journal of Translational Medicine, 2025 • February 11, 2025
This study investigates the role of Follistatin-like 1 (FSTL1) in nucleus pulposus-derived mesenchymal stem cell (NP-MSC) apoptosis and intervertebral disc degeneration (IVDD). The findings reveal tha...
KEY FINDING: FSTL1 expression is elevated in NP-MSCs from degenerated intervertebral discs in both humans and rats.
PNAS, 2025 • February 27, 2025
We previously showed that decreasing LLPS of RNA–protein granules containing the core stress granule protein G3BP1 accelerates the regeneration of injured PNS axons. Expression of G3BP1’s conserved B-...
KEY FINDING: G3BP1 B-domain expression was found to promote axon regeneration in the transected spinal cord provided with a permissive peripheral nerve graft (PNG) as well as in crushed optic nerve.
Stem Cell Research & Therapy, 2025 • February 20, 2025
This research investigates the therapeutic potential of nasal mucosa-derived mesenchymal stem cells (EMSCs) modified to overexpress neuropeptide S (NPS) for treating spinal cord injury (SCI) in rats. ...
KEY FINDING: NPS-overexpressing EMSCs showed greater cell survival in the transplanted area compared with stem cells without gene modification within 4 weeks after spinal cord implantation in rats.
Cell Reports Medicine, 2025 • March 18, 2025
The study develops injectable GelMA hydrogels with controlled mechanical properties containing targeting miR-222-engineered extracellular vesicles (TeEVs). These injectable patches facilitate the prec...
KEY FINDING: Targeting miR-222-engineered EVs are incorporated in mechanical GEL hydrogels
PNAS, 2025 • March 5, 2025
This study investigated the functionality and efficiency of AAVs to transduce cells in the axolotl brain, spinal cord, and retina, finding that AAV8, AAV9, and AAVPHP.eB are the most efficient viral v...
KEY FINDING: AAV8, AAV9, and AAVPHP.eB are efficient viral vectors for gene transfer in the axolotl brain and spinal cord.
Stem Cell Research & Therapy, 2025 • January 3, 2025
Spinal cord injury (SCI) is a serious neurological disorder that causes loss of mobility, pain, and autonomic dysfunction, resulting in altered sensation and devastating loss of function. With the con...
KEY FINDING: DPSCs are involved in nerve repair in SCI through various pathways, such as anti-inflammatory effects, promotion of axonal regeneration, reduction of apoptosis, and immunomodulation.