Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,361-1,370 of 2,298 results
Bioeng Transl Med, 2024 • January 1, 2024
This study introduces a novel approach for spinal cord injury (SCI) repair using plant-derived exosomes (PEs) extracted from Lycium barbarum L., loaded with isoliquiritigenin (ISL) and integrated into...
KEY FINDING: PEs from L. barbarum L. possess anti-inflammatory and neuronal differentiation promotion capabilities, showing enhanced neural differentiation compared to exosomes from ectomesenchymal stem cells (EMSCs).
Materials Today Bio, 2024 • November 12, 2024
This study introduces a novel poly(lipoic acid)/poly(dopamine) adhesive hydrogel loaded with methylcobalamin and tellurium nanoenzymes (LaD/Me/Te-h) for spinal cord injury (SCI) repair. The LaD/Me/Te-...
KEY FINDING: The LaD/Me/Te-h hydrogel demonstrated superior radical scavenging abilities compared to La-h and LaD/Me-h groups, attributed to antioxidant polyphenol groups and Te nanoparticles.
Cellular and Molecular Life Sciences, 2024 • July 5, 2024
This study investigates the use of iPSC/ESC-derived pyramidal precursor cells (PNPs) for treating spinal cord injury (SCI) in a rodent model. PNPs had a significant effect on behavioral recovery follo...
KEY FINDING: Transplantation of iPSC-derived PNPs into SCI rats significantly improved their motor functions compared to the control group.
Journal of Translational Medicine, 2024 • July 3, 2024
This study demonstrates that metformin enhances the proliferation and neuronal differentiation of neural stem cells (NSCs), both in vitro and in vivo. Metformin treatment reverses erastin-induced chan...
KEY FINDING: Metformin promotes the proliferation and neuronal differentiation of NSCs both in vitro and in vivo.
Stem Cell Research & Therapy, 2024 • July 11, 2024
This clinical trial investigated the safety and feasibility of intravenous administration of allogenic Muse cells for treating human cervical traumatic spinal cord injury (SCI). The study involved 10 ...
KEY FINDING: The study found no serious safety issues with using Muse cells in this way.
Nature Communications, 2024 • August 6, 2024
This study presents an atlas of the dynamic responses across major spinal cell types during early, intermediate and late stages of regeneration in adult zebrafish. The research uncovers neurons as pote...
KEY FINDING: Neurogenesis of glutamatergic and GABAergic neurons restores the excitatory/inhibitory balance after injury, which is crucial for proper neural function.
bioRxiv, 2024 • August 9, 2024
Regenerating limbs retain their proximodistal (PD) positional identity following amputation. Here, we show that RA breakdown via CYP26B1 is essential for determining RA signaling levels within blastem...
KEY FINDING: CYP26B1, an enzyme that breaks down retinoic acid, is more highly expressed in distal blastemas (DBs) than proximal blastemas (PBs).
Frontiers in Molecular Neuroscience, 2024 • August 7, 2024
This study systematically reviews and meta-analyzes the efficacy of bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exo) in improving spinal cord injury (SCI) in rat models. The meta-analysi...
KEY FINDING: BMSCs-Exo significantly improved the BBB score in SCI rats (WMD = 3.47, 95% CI [3.31, 3.63]), indicating improved motor function.
Stem Cell Research & Therapy, 2024 • January 1, 2024
This study demonstrated that intrathecal administration of allogeneic HUC-MSCs-exosomes is safe in patients with subacute SCI. Moreover, it seems that this therapy might be associated with potential c...
KEY FINDING: The intrathecal injection of allogeneic HUC-MSCs-exosomes was safe and well tolerated. No early or late adverse event (AE) attributable to the study intervention was observed.
Smart Medicine, 2023 • January 1, 2023
This study introduces bFGF‐loaded GelMA microspheres with excellent biocompatibility and sustained drug release for spinal cord injury repair. The microspheres are prepared using microfluidic technolo...
KEY FINDING: bFGF-loaded GelMA microspheres significantly promoted the proliferation and differentiation of neural stem cells in vitro.