Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,371-1,380 of 2,298 results
Smart Medicine, 2022 • October 20, 2022
This review summarizes recent advances in cell engineering, tissue engineering, and combined therapies for spinal cord injury (SCI) treatment. It covers cell-based strategies with neuroprotective and ...
KEY FINDING: Recent advances in bioengineering have shown that therapies based on cells, biomaterials, and biomolecules are effective in spinal cord regeneration.
Smart Med., 2022 • September 1, 2022
This review provides an overview of recent research progress in iPSC induction methods and clinical applications. The review comprehensively introduces approaches involving biological, chemical, and p...
KEY FINDING: iPSCs are now widely used to study various clinical diseases of hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries.
Cells, 2024 • August 8, 2024
This study investigates the effectiveness of predegenerated peripheral nerve (PPN) transplantation, alone and in combination with neural precursor cells (NPCs) and Tol-51, in promoting axonal regenera...
KEY FINDING: PPN implantation after scar removal one month after SCI induces the regeneration of descending and ascending axons within and beyond the PPN, which connects the rostral and caudal spinal cord segments.
Int. J. Mol. Sci., 2024 • August 10, 2024
This study explores the use of human neural stem cells (hNSCs) overexpressing neurexins (NRXNs) and neuroligins (NLGNs) to promote synaptic regeneration in a spinal cord injury (SCI) model. The result...
KEY FINDING: Overexpression of NRXNs and NLGNs in neural stem cells upregulated synaptic markers like synaptophysin, PSD95, VAMP2, and synapsin.
Materials Today Bio, 2024 • June 3, 2024
This study introduces a novel magnetically responsive injectable hydrogel composed of gellan gum, hyaluronic acid, collagen, and magnetic nanoparticles (MNPs) for aligned tissue regeneration. The hydr...
KEY FINDING: The hydrogel exhibits mechanical properties comparable to human soft tissues, such as skeletal muscle, suggesting its suitability for tissue engineering applications.
Tissue Eng Regen Med, 2024 • August 31, 2024
The study aimed to identify the early events associated with enhanced skin regeneration in a fetal sheep full thickness wound model using collagen scaffolds functionalized with heparin, fibroblast grow...
KEY FINDING: COL-HEP/GF scaffolds induce a tight but subtle control over cell signaling and extracellular matrix organization.
Iranian Journal of Basic Medical Sciences, 2024 • January 1, 2024
This study investigates the therapeutic potential of hAMSCs-derived exosomes for acute TSCI in rats, finding that intravenous administration of these exosomes promotes functional recovery. The exosome...
KEY FINDING: hAMSCs-derived exosomes significantly reduced the numbers of ED1+ macrophages/microglia and caspase-3+cells and decreased the levels of reactive oxygen species, myeloperoxidase activity and inflammatory cytokines.
The Journal of Neuroscience, 2024 • October 23, 2024
The study identifies synaptotagmin 4 (Syt4) as a novel regulator of axon regrowth following CNS injury. Loss-of-function screening combined with phenotypic analysis revealed that Syt4 knockdown inhibi...
KEY FINDING: Syt4 knockdown in cortical neurons inhibits neurite elongation in vitro, suggesting a role in axon growth.
Nature Communications, 2024 • January 1, 2024
This is an author correction to a previously published article in Nature Communications. The correction addresses a misspelling of one of the author's names; Ruth Telvin was corrected to Ruth Tevlin. ...
KEY FINDING: The only finding is the correction of the author's name from Ruth Telvin to Ruth Tevlin.
Int. J. Mol. Sci., 2024 • September 4, 2024
3D bioprinting shows promise in SCI repair by creating scaffolds that mimic the native spinal cord architecture, utilizing bioinks and stem cells. Innovative strategies improve electrical conductivity...
KEY FINDING: 3D bioprinting enables the precise creation of scaffolds mimicking the spinal cord's structure, with the ability to embed living cells directly, promoting their survival and integration.