Regenerative Medicine Research

KEY FINDING: Dysfunctional pathological microenvironment in SCI comprises excessive inflammation, deposition of inhibitory molecules, neurotrophic factor deprivation, glial scar formation, and imbalance of vascular function.

KEY FINDING: Combination cell transplantation of BDNF-eMSC and iMNP significantly improved behavioral recovery in a chronic SCI rat model compared to single-cell transplantation.

KEY FINDING: The combination of melatonin and dexamethasone showed suitable neuroprotective activities by reducing neutrophil infiltration, cytokine levels, tissue damage, inducible nitric oxide synthase expression, and apoptosis in SCI-treated mice, and motor recovery was also ameliorated.

KEY FINDING: The decellularization process effectively removed cellular components from spinal cords and sciatic nerves while preserving the ECM structure.

KEY FINDING: Xenogeneic sheep bone marrow MSCs can engraft at the injury site in a rat SCI model.

KEY FINDING: iPSCs have the potential to differentiate into neurons, astrocytes, and oligodendrocytes, replacing damaged cells, regulating the spinal cord microenvironment, and promoting axon and myelin sheath regeneration.

KEY FINDING: Apoptotic PBMCs attenuated LPS-induced spillage of IL-6 and IL-1β in co-cultured monocytes and PBMCs. Irradiated PBMCs reduced T-cell proliferation.

KEY FINDING: NSCs represent a promising regenerative strategy for SCI treatment due to their ability to differentiate into neurons and glial cells, of which, oligodendrocytes play a crucial role in myelin regeneration, demyelination repair and neural circuit reconstruction.

KEY FINDING: Spinal cord regeneration can be explained by a potential signaling mechanism operating under a reaction-diffusion scheme.

KEY FINDING: PPT NMs effectively mitigated LPS-stimulated cell apoptosis, in a dose-dependent manner, suggesting an anti-apoptotic effect.