Regenerative Medicine Research

KEY FINDING: The xanthohumol-loaded PLGA scaffolds exhibited anti-inflammatory properties in vitro, reducing the expression of inflammatory cytokines (IL-1β and TNF-α) in macrophages.

KEY FINDING: EVs play a significant role in OA pathogenesis by influencing inflammation, metabolism, and cellular senescence within joint tissues.

KEY FINDING: At 10 weeks post-lesion, injured lampreys recovered normal appearing locomotion.

KEY FINDING: Transfection of SHH with cationic liposomes exhibited more effect in RMSCs than lipofectamine 2000.

KEY FINDING: CSPCs exhibit significant heterogeneity that is closely associated with the progression of OA, indicating that the characteristics of CSPCs change during OA progression.

KEY FINDING: NSCs have regenerative effects in SCI animal models through paracrine effects and direct neuronal differentiation, restoring synaptic connectivity and neural networks.

KEY FINDING: Microtubule stabilization and actin dynamics are critical for axon growth and regeneration. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.

KEY FINDING: Ginsenoside Rg1 can directly transdifferentiate reactive astrocytes into neuron-like cells (iNs) in rats, without going through a neural progenitor stage.

KEY FINDING: The combined use of tetrahedral framework nucleic acid (tFNA) with neural stem cells (NSCs) significantly improved functional recovery in SCI models, as measured by the BBB locomotion test.

KEY FINDING: NSC from E14 mice on multichannel PLG scaffold increases density of axons and myelin regeneration and leads to a more rapid and functional recovery