Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,081-1,090 of 2,298 results
Front. Cell Dev. Biol., 2022 • June 29, 2022
This review examines the factors that regulate adult neural stem and progenitor cell (aNSPC) cell cycle dynamics in teleosts, particularly focusing on studies using the zebrafish model. It highlights h...
KEY FINDING: Social interactions, stress, hormones, diet, and sensory stimuli significantly influence aNSPC activity in the zebrafish CNS.
Cell Reports Methods, 2022 • July 18, 2022
The study reports methods for culturing adult central nervous system neurons in large numbers and across multiple brain regions for extended time periods. These cultures exhibit key characteristics of...
KEY FINDING: Adult neurons in culture from various brain regions retained several features characteristic of their in vivo cell morphology, including distinct morphologies for motor cortex, cerebellar Purkinje, hippocampal, reticulospinal, and spinal cord alpha motor neurons.
Biomedicines, 2022 • July 7, 2022
This study investigated the effects of low-energy ESWT applied in the subacute and chronic phases of SCI on recovery in a rat spinal cord contusion model. Rats receiving ESWT showed significant improve...
KEY FINDING: Rats receiving ESWT showed significant improvement in motor function in both a subacute and a chronic experimental setting.
Int. J. Mol. Sci., 2022 • July 7, 2022
This review examines the use of mesenchymal stem cells (MSCs) in combination with biomaterial scaffolds as a potential therapeutic strategy for spinal cord injury (SCI). The focus is on the cellular a...
KEY FINDING: Collagen scaffolds combined with MSCs show promise due to their biocompatibility and ability to promote axonal regeneration and reduce inflammation in SCI models.
Cellular and Molecular Life Sciences, 2022 • July 29, 2022
This study demonstrates that severe spinal contusion in adult rats causes transcriptional dysregulation, which persists from early subacute to chronic stages of SCI and affects nearly 20,000 genes. Th...
KEY FINDING: SCI induces robust transcriptional dysregulation affecting nearly 20,000 genes, with significant downregulation of cAMP signaling components.
Nature Communications, 2022 • August 8, 2022
The study uses systems genomics to identify REST as an upstream suppressor of pro-regenerative gene programs in the CNS. Validation in multiple paradigms showed improved regeneration of corticospinal ...
KEY FINDING: REST acts as an upstream suppressor of the intrinsic regenerative program in the CNS.
Cellular & Molecular Biology Letters, 2022 • September 2, 2022
This study investigates the evolutionary dynamics and function of progranulins (PGRNs) in lampreys, primitive vertebrates known for their regenerative abilities. Four genes encoding PGRNs were identif...
KEY FINDING: Four PGRN genes were identified in lampreys: one long form (Lr-PGRN-L) and three short forms (Lr-PGRN-S1, Lr-PGRN-S2, and Lr-PGRN-S3).
PLOS ONE, 2022 • August 5, 2022
This study investigated the longitudinal electrophysiological changes in a spinal cord injury (SCI) rat model after mesenchymal stem cell (MSC) transplantation, focusing on the relationship between tc...
KEY FINDING: tcMEP waveforms appeared earlier in MSC-transplanted rats compared to PBS-administered rats, with the earliest appearance observed 7 days after SCI.
Signal Transduction and Targeted Therapy, 2022 • July 21, 2022
This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human dise...
KEY FINDING: BM-MSCs are potentially good candidates for brain and spinal cord injury treatment.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This study explored the potential clinical application roles of hADSCs-Exos encapsulated in functional PF-127 hydrogel in wound healing. The hADSCs-Exos/PF-127 combination could promote wound healing ...
KEY FINDING: PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased expression of Ki67, α-SMA, and CD31, facilitated collagen synthesis (Collagen I, Collagen III), up-regulated expression of skin barrier proteins (KRT1, AQP3), and reduced inflammation (IL-6, TNF-α, CD68, CD206).