Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,071-1,080 of 2,298 results
Journal of Tissue Engineering and Regenerative Medicine, 2022 • May 24, 2022
This study investigated the safety and feasibility of transplanting hydrogel-encapsulated autologous olfactory ensheathing cells (mOECs) expressing chondroitinase ABC (chABC) into the spinal cords of ...
KEY FINDING: The intraspinal transplantation of hydrogel‐encapsulated autologous mucosal olfactory ensheathing cell (mOEC) populations expressing chondroitinase ABC (chABC) is feasible and safe in paraplegic dogs in a clinical setting.
Frontiers in Cellular Neuroscience, 2022 • May 27, 2022
This editorial highlights recent advances in CNS repair, regeneration, and neuroplasticity, emphasizing preclinical research on therapeutic strategies targeting various neurological conditions like TB...
KEY FINDING: Identified druggable targets to intervene with secondary brain injuries like ischemia, hemorrhage, and mitochondrial dysfunction after TBI.
Ann Transl Med, 2022 • May 1, 2022
This study investigated the potential of human dental pulp stem cells (hDPSCs) and platelet-rich plasma (PRP) in treating spinal cord injuries in rats. The researchers found that hDPSCs can differenti...
KEY FINDING: hDPSCs exhibit differentiation potential and can transform into neural cells both in vitro and in vivo.
J. Dev. Biol, 2022 • June 1, 2022
This study characterized ependymal cells from the trunk spinal cord of the leopard gecko, revealing a heterogenous population including radial glia and neuronal-like cells. The researchers determined ...
KEY FINDING: Ependymal cells of the trunk spinal cord express SOX2, indicating their potential as neural stem/progenitor cells.
BMC Neuroscience, 2022 • July 7, 2022
This study investigates the role of Cacna2d2 (α2δ2) in axonal regeneration following surgical decompression in a rat model of cervical spondylotic myelopathy (CSM). The researchers found that α2δ2 exp...
KEY FINDING: Following surgical decompression in a rat model of CSM, the expression levels of α2δ2 in the anterior horn of the spinal cord decreased, while the expression levels of 5HT and GAP43 increased.
Neurospine, 2022 • June 1, 2022
Alginate hydrogels show promise as a treatment modality for SCI due to their versatility, biocompatibility, and biomechanical similarity to the ECM. Alginate hydrogels can be modified in their chemica...
KEY FINDING: Alginate hydrogels are efficient substrates for tissue engineering, drug delivery, neural regeneration, and cell-based therapies for spinal cord injury repair.
Regenerative Biomaterials, 2022 • June 6, 2022
This study investigated the effectiveness of a 3D bioprinted sodium alginate/gelatin scaffold loaded with neural stem cells (NSCs) and oligodendrocytes (OLGs) for promoting nerve regeneration after sp...
KEY FINDING: The 3D bioprinting scaffold loaded with neural stem cells (NSCs) and oligodendrocytes (OLGs) markedly promoted the recovery of motor function after complete-transection spinal cord injury (SCI) in rats.
Neural Regeneration Research, 2023 • January 1, 2023
Central axons fail to regenerate appropriately after a traumatic lesion. Therefore, the damaged connections are not reestablished after SCI, leaving permanent dysfunctions. Among several therapeutic i...
KEY FINDING: Molecular compounds, including drugs, growth factors, enzymes, and purines, are being explored in preclinical and clinical studies to treat spinal cord injuries.
Glia, 2022 • October 1, 2022
This study demonstrates the capacity of digoxin to induce OPC differentiation in vitro, to robustly stimulate myelination in vivo in the chemically-induced cuprizone and lysophosphatidylcholine (LPC) ...
KEY FINDING: Digoxin regulated multiple genes in oligodendrocyte progenitor cells (OPCs) essential for oligodendrocyte (OL) differentiation in vitro, promoted OL differentiation both in vitro and in vivo in female naïve C57BL/6J (B6) mice, and stimulated recovery of myelinated axons in B6 mice following demyelination in the corpus callosum induced by cuprizone and spinal cord demyelination induced by lysophosphatidylcholine (LPC), respectively.
Front. Integr. Neurosci., 2022 • June 30, 2022
This study investigates the impact of ChABC on promoting axonal regeneration and spinal neuronal plasticity following complete spinal cord transection (CST) in rats. The key finding is that ChABC admi...
KEY FINDING: ChABC administration promotes the passage of descending 5-HT axons through the fibrous scar at the lesion site.