Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice

This study identifies REST, a protein that controls gene expression, as a key factor that prevents nerve cells in the brain and spinal cord from regrowing after injury. By studying gene activity after spinal cord and optic nerve injuries in mice, the researchers found that blocking REST allowed nerve fibers to regenerate, suggesting a new target for therapies to promote recovery from CNS injuries. The study used advanced techniques to analyze gene networks and pinpoint REST as a master regulator, then validated these findings by showing improved nerve regeneration when REST was blocked in injured mice.

• 1
  REST acts as an upstream suppressor of the intrinsic regenerative program in the CNS.
• 2
  Cell type-specific deletions of REST in mature mice improved regeneration of the corticospinal tract and optic nerve after injury.
• 3
  Counteracting REST resulted in increased regeneration in two different models of CNS injury in vivo—optic nerve crush and complete spinal cord injury.