Regenerative Medicine Research

KEY FINDING: Wnt signaling is necessary for the early stages of limb bud outgrowth. Treatment with C59 at stage 40 permanently inhibited limb development.

KEY FINDING: The protocol details two methods for spinal cord transection: incision and perforation lesion, both yielding comparable regeneration kinetics with reproducibility, high throughput, and low mortality.

KEY FINDING: Regeneratively competent species predominantly display apoptotic, as opposed to necrotic, cell death following a CNS injury. Notably, necrosis stimulates a pro-inflammatory immune response that leads to further damage, whereas apoptosis is typically anti-inflammatory.

KEY FINDING: Virus-mediated Gsx1 expression leads to locomotor functional recovery while Nkx6.1 expression does not have a significant benefit in regaining locomotor function.

KEY FINDING: AFG implantation induced histologically obvious white matter regeneration, consisting of a large area of consecutive, compact, and aligned nerve fibers in canine T12 spinal cord injuries.

KEY FINDING: RAG and ATF genes are differentially expressed in early differentiated neurons versus undifferentiated neurospheres, with ATF3 showing the highest difference in expression.

KEY FINDING: PNG transplantation has shown potential for improved recovery, even for incomplete injuries, due to its unique ability to bypass damaged long tracts, provide myelination, and be surgically directed toward specific sites in the spinal cord.

KEY FINDING: CAG promoter-driven Cre-ERT2/loxP system showed conditional labeling of muscle, epidermal, and interstitial cells in tadpole tails and froglet legs upon 4OHT treatment.

KEY FINDING: The MgO/PLCL scaffold releases magnesium ions that attenuate cell apoptosis by blocking calcium influx in the injured spinal cord.

KEY FINDING: The ROS-scavenging hydrogel effectively encapsulated BMSCs and reduced the production of endogenous ROS in vivo.