Regenerative Medicine Research

KEY FINDING: The apical papilla reduced inflammation at the lesion site by decreasing the concentration of pro-inflammatory cytokines.

KEY FINDING: Axonal regeneration in the CNS is limited by the white matter environment and its cytoarchitecture.

KEY FINDING: Materials-potentiated cell engineering strategies are to endow immune cells with different supportive components (also known as backpack strategies), or functional materials to enhance their anti-tumor effects, prevent and rescue their dysfunction, maintain and restore their anti-tumor phenotype

KEY FINDING: Transplantation of ahNSCs significantly improved motor function recovery in SCI animal models, with higher BBB scores observed in medium and high dosage groups compared to the vehicle group.

KEY FINDING: Very recent breakthroughs demonstrated the progressive maturation and functional integration of dormant precursors as excitatory principal neurons in the murine olfactory cortex.

KEY FINDING: Treatment with agathisflavone alone or with agathisflavone-treated rMSCs protected injured spinal cord tissue, increased expression of NGF, GDNF, and arginase, and reduced macrophage infiltrate.

KEY FINDING: The erratum addresses the absence of supplementary figures in the initial publication.

KEY FINDING: There remains limited commercial interest in developing innovative therapies for SCI due to multiple mechanisms that drive delayed injury and a low incidence of injuries each year worldwide.

KEY FINDING: Genetically targeting B-RAF and PTEN in DRG neurons of adult mice enables many DC axons to enter, cross, and grow beyond the lesion site after SCI, with some axons reaching approximately 2 mm rostral to the lesion by 3 weeks post-injury.

KEY FINDING: CNS neurons can revert to an embryonic-like growth state ("redevelopment") after injury, facilitating axon regeneration.