Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,061-1,070 of 2,298 results
Spinal Cord, 2022 • May 23, 2022
This study provides a comprehensive summary of biomaterial-based combination strategies tested in preclinical SCI models and demonstrates the effectiveness of these strategies overall for improving lo...
KEY FINDING: Treatment with BMO resulted in a significant improvement in locomotor recovery and axonal regeneration.
Journal of Neurotrauma, 2022 • December 1, 2022
This study investigates the morphological changes in corticospinal tract (CST) pathways after intravenous infusion of mesenchymal stem cells (MSCs) in a rat model of spinal cord injury (SCI). The stud...
KEY FINDING: MSC infusion leads to increased axonal connections between the main CST pathway (dCST) and axons in the lateral funiculus, both above and below the injury.
Curr Opin Genet Dev, 2022 • August 1, 2022
This review discusses the role of ependymal glial cells in spinal cord regeneration, particularly their origin and activation after injury. The origin of NSCs remains unclear, with possibilities inclu...
KEY FINDING: Ependymal glial cells in regeneration-competent species express Sox2 and act as neural stem cells (NSCs) after spinal cord injury, rapidly proliferating to regenerate the missing tissue.
Biology, 2022 • May 20, 2022
The treatment of spinal cord injury aims to reconstruct the fiber connection and restore the interrupted neural pathways. Our results indicate that the combined transplantation of human ADSCs with RADA...
KEY FINDING: ADSCs+RADA16-RGD could improve neuron survival and promote axonal growth.
Stem Cells Translational Medicine, 2022 • February 19, 2022
CNS trauma remains incurable, but cell therapy shows potential. Exogenous stem cell transplantation or modulation of endogenous stem and progenitor cells can protect tissue, compensate for cell loss, ...
KEY FINDING: Stem cell transplantation can promote neuroprotection, reduce degeneration, and improve functional outcomes after experimental SCI.
Cell Communication and Signaling, 2022 • April 30, 2022
This study identifies and characterizes a novel natural antisense RNA, Foxk1-AS, which is transcribed from the opposite strand of the Foxk1 gene. Foxk1-AS is found to be located within the 3' UTR of F...
KEY FINDING: Foxk1-AS is a natural antisense RNA transcribed from the opposite strand of the Foxk1 gene and is completely incorporated in the 3′ UTR of Foxk1.
Dev Biol, 2022 • August 1, 2022
This study demonstrates that post-synaptic dendrites in the vertebrate spinal cord (zebrafish) can regenerate after injury, expanding the understanding of neuronal regeneration capabilities. The resea...
KEY FINDING: Zebrafish motor neurons are capable of regenerating dendrites after laser microsurgery, even when all dendrites are removed.
Frontiers in Bioengineering and Biotechnology, 2022 • May 13, 2022
This editorial highlights the growing need for effective strategies to repair musculoskeletal tissue, especially tendon injuries and chronic tendinopathies. The special issue of Frontiers in Bioengine...
KEY FINDING: Pathological inflammation differs from reparative inflammation, and immunomodulatory therapies could be effective if timed correctly.
NEURAL REGENERATION RESEARCH, 2022 • December 1, 2022
This research investigates the impact of long-lasting oscillating field stimulation (OFS) on rats after spinal cord injury (SCI). The study compared rats with SCI, rats with SCI and active OFS, and r...
KEY FINDING: Epidural OFS reduces tissue and myelin loss after SCI, particularly in areas near the injury.
Theranostics, 2022 • May 16, 2022
This study investigates the potential of grafted human embryonic stem cell (ESC)-derived astroglia to repair spinal cord lesions by modulating the host immune response. The key finding is that grafted...
KEY FINDING: Transplanted astroglia (NPC- or Olig2PC-Astros) survived in the spinal cord lesion area and aided in wound healing by decreasing scar formation.