Physiology Research

KEY FINDING: The modified protocol significantly improves the yield of viable, intact myofibers compared to previous methods, achieving approximately 2300–3100 myofibers from two FDB muscles of a single mouse.

KEY FINDING: Hydrogen sulfide (H2S) has anti-inflammatory and anti-apoptotic effects and can protect the spinal cord. It reduces oxidative stress and promotes axon growth.

KEY FINDING: Bl6 mice are more resistant to IMAT formation compared to 129S and CD1 strains.

KEY FINDING: LGI1 is highly expressed in dorsal root ganglion (DRG) and spinal cord dorsal horn neurons in both mouse and human.

KEY FINDING: MCT1 expression is markedly decreased in endothelial cells (ECs) post-SCI, disrupting lactate transport to neurons.

KEY FINDING: Neither Acomys nor Mus recovered lost muscle mass or myofiber number within three months following VML injury, and Acomys also failed to recover force production better than Mus.

KEY FINDING: In humans, concurrent application of a noxious conditioning stimulus did not affect pain ratings to a single pinprick stimulus, repetitive stimulation or the wind-­up ratio.

KEY FINDING: ULF current can acutely and reversibly interrupt signaling between sensory afferent fibers and relay neurons of the thalamus.

KEY FINDING: After SCI, the early spinal reflex component decreases in amplitude, while a late component emerges and becomes dominant, correlating with walking capacity impairment.

KEY FINDING: Cardiac injury leads to abnormal signaling in the nervous system, resulting in excessive sympathetic activity and potentially fatal arrhythmias.