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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Physiology Research

Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.

Showing 301-310 of 321 results

Regenerative MedicinePhysiology

Tendon Vasculature in Health and Disease

Frontiers in Physiology, 2015 • November 18, 2015

This review provides an overview of the role of tendon vasculature in healthy and chronically diseased tendon tissue as well as its relevance for tendon repair. The nature and the role of perivascular...

KEY FINDING: Tendons have a more complex vascular network than previously believed, with vessels entering from musculo-tendineous junctions, bone insertion sites, and the paratenon.

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PhysiologyNeurologyNeurorehabilitation

Ipsilateral motor evoked potentials in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis

Neural Regeneration Research, 2019 • June 1, 2019

This case study examined motor output reorganization in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis, focusing on ipsilateral corticospinal pathways using transcranial ...

KEY FINDING: The patient with Rasmussen encephalitis showed higher median amplitudes of ipsilateral motor evoked potentials (MEPs) in the first dorsal interosseous and wrist extensors muscles compared to healthy controls.

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PhysiologyNeurologySurgery

Musculotendon adaptations and preservation of spinal reflex pathways following agonist-to-antagonist tendon transfer

Physiol Rep, 2017 • May 1, 2017

This study investigated how musculotendon adaptations and spinal reflex reorganization influence outcomes after agonist-to-antagonist tendon transfer in cats. The main findings revealed the formation ...

KEY FINDING: New tendinous connections formed after tendon transfer, often near original insertion sites, potentially compromising the mechanical action of the transferred muscle.

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AnesthesiologyRegenerative MedicinePhysiology

Propofol (2,6-diisopropylphenol) is an applicable immersion anesthetic in the axolotl with potential uses in hemodynamic and neurophysiological experiments

Regeneration, 2017 • January 1, 2017

This study investigated the applicability of propofol as an immersion anesthetic in axolotls, focusing on its effects on cardiovascular function, action potential propagation in the spinal cord, and g...

KEY FINDING: Propofol has significantly less cardiovascular effect than benzocaine and MS-222 when used as an anesthetic in axolotls.

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PhysiologyVeterinary MedicinePediatrics

Quantitative analysis of motor evoked potentials in the neonatal lamb

Scientific Reports, 2017 • November 1, 2017

This study aimed to evaluate the feasibility and reliability of standardized motor evoked potential (MEP) recording and analysis in neonatal lambs. The researchers developed an algorithm for MEP quant...

KEY FINDING: MEPs could be easily recorded in neonatal lambs using transcranial motor cortex stimulation.

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Spinal Cord InjuryCardiovascular SciencePhysiology

Chronic mild hypoxia promotes profound vascular remodeling in spinal cord blood vessels, preferentially in white matter, via an α5β1 integrin-mediated mechanism

Angiogenesis, 2018 • May 1, 2018

This study investigates the impact of chronic mild hypoxia (CMH) on vascular remodeling in the spinal cord, revealing that CMH promotes endothelial proliferation, angiogenesis, and arteriogenesis. The...

KEY FINDING: Chronic mild hypoxia (CMH) promotes endothelial proliferation and increased vascularity in spinal cord blood vessels through angiogenesis and arteriogenesis.

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UrologyPhysiologyResearch Methodology & Design

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Journal of Visualized Experiments, 2018 • January 30, 2018

This article describes a surgical and measurement protocol for assessing lower urinary tract function in awake rats, using implanted catheters and electrodes to simultaneously monitor the urinary blad...

KEY FINDING: The success rate for the surgical procedure and maintaining the implanted devices intact is approximately 80%.

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PhysiologyGenetics

Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels

CHANNELS, 2018 • May 22, 2018

This study investigates the role of a conserved negatively charged residue (D4) in the voltage-sensing domain IV (VSD IV) of CaV1.2 and CaV1.3 calcium channels, focusing on its impact on channel gatin...

KEY FINDING: In both CaV1.3 and CaV1.2 channels, a mutation neutralizing the D4 charge (D4N) in voltage-sensing domain IV (VSD IV) resulted in a right-shift of the voltage-dependence of activation by approximately 5 mV.

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Regenerative MedicinePhysiologyNeurology

Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging

Biophysical Journal, 2018 • September 4, 2018

This study uses Brillouin microscopy to map the mechanical properties of spinal cord tissue in living zebrafish larvae during development and after spinal cord injury, providing a non-destructive metho...

KEY FINDING: The Brillouin shift within the spinal cord remained comparable during development, indicating stable mechanical properties.

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Regenerative MedicinePhysiologyGenetics

More Than Just a Bandage: Closing the Gap Between Injury and Appendage Regeneration

Frontiers in Physiology, 2019 • February 8, 2019

This review discusses the biophysical, biochemical, and epigenetic processes involved in regenerative healing in amphibians, particularly tail and limb regeneration in Xenopus. The review highlights t...

KEY FINDING: Reactive oxygen species (ROS) signaling is rapidly activated after injury and is required for tail regeneration. Inhibition of ROS prevents full tail regeneration and affects the activation of Wnt signaling pathways.

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