Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 131-140 of 321 results
Eur J Appl Physiol, 2019 • December 1, 2019
The study characterized left ventricular diastolic filling and volume during an exercise challenge in adults with incomplete cervical spinal cord injury (icSCI). The subjects with icSCI in this study ...
KEY FINDING: End-diastolic volume (EDV) was significantly reduced in icSCI compared to CON at peak exercise and at isomax.
Scientific Reports, 2019 • November 18, 2019
The study refines CMAP and MUNE methods for assessing spinal motor unit input in rat forelimbs and hindlimbs, demonstrating robustness and alignment with anatomical LMN counts. Validation in SOD1 muta...
KEY FINDING: CMAP and MUNE recordings are robust with low coefficients of variability in both forelimb and hindlimb of rats.
eLife, 2019 • December 3, 2019
This study establishes a murine model of sepsis with ICU-like interventions to investigate chronic muscle weakness in survivors. The research demonstrates that sepsis survivors have prolonged muscle w...
KEY FINDING: Sepsis survivors exhibit chronic muscle weakness for at least one month, even after muscle mass recovery.
J Comp Neurol, 2020 • June 15, 2020
This study investigated the molecular and histologic responses to spinal cord injury (SCI) in spiny mice (Acomys cahirinus) compared to C57BL/6 mice (Mus). Gene array and RT-qPCR results showed that s...
KEY FINDING: Spiny mice showed increased expression of genes related to neurogenesis and regeneration after spinal cord injury compared to C57BL/6 mice.
Scientific Reports, 2019 • December 19, 2019
The study analyzed blood pressure (BP) and heart rate (HR) responses to electrical stimulations at each DCN from T6 to L1 at 0.5 mA to activate A-fiber alone or 5 mA to activate both A- and C-fibers a...
KEY FINDING: Stimulation strength showed a large effect on BP changes dependent on C-fibers whereas HR changes were dependent on A-fibers.
Top Spinal Cord Inj Rehabil, 2019 • October 1, 2019
This systematic review examined the use of electrophysiological (EP) outcome measures in spinal cord injury (SCI) clinical trials, revealing significant variation in assessment methods and reporting p...
KEY FINDING: The most commonly used electrophysiological measures were electromyography (EMG), motor evoked potentials (MEPs), somatosensory evoked potentials (SSEPs), and H-reflex.
PLoS ONE, 2019 • December 26, 2019
This study compared the recovery cycles of H reflexes and posterior root-muscle (PRM) reflexes in individuals with and without spinal cord injury (SCI). The findings indicate that PRM reflexes, but no...
KEY FINDING: The recovery cycles of H reflexes did not differ significantly between neurologically intact individuals and those with SCI.
Spinal Cord Series and Cases, 2020 • January 1, 2020
This pilot study investigated the feasibility of overnight electrical stimulation (ES) to activate leg muscles in individuals with spinal cord injury (SCI). The study found that overnight ES-induced m...
KEY FINDING: After 8 hours of electrical stimulation, muscles still contracted, indicating the method's feasibility for prolonged use.
Nature Communications, 2020 • February 21, 2020
Denervation of skeletal muscles leads to atrophy, marked by cellular changes like increased plasma membrane permeability and accelerated protein catabolism. The study aimed to identify factors prevent...
KEY FINDING: Acetylcholine (ACh) and its analogs repress the expression of connexin43 and connexin45 hemichannels, which are associated with muscle atrophy.
Clin Auton Res, 2021 • April 1, 2021
The study defines differences in heart rate and blood pressure variability (HRV/BPV) after spinal cord injury (SCI) compared with uninjured controls, and determines if variabilities are impacted by wh...
KEY FINDING: Individuals with SCI exhibited significantly lower LF and HF HRV, as well as LF BPV, compared to uninjured controls.