Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus

This study compares the response to spinal cord injury (SCI) in spiny mice (Acomys cahirinus) and C57BL/6 mice (Mus). The researchers hypothesized that spiny mice would show reduced inflammation and fibrosis after SCI compared to C57BL/6 mice. The study examined gene expression and tissue samples to assess inflammation, fibrosis, and regeneration markers in both species after SCI.

• 1
  Spiny mice showed increased expression of genes related to neurogenesis and regeneration after spinal cord injury compared to C57BL/6 mice.
• 2
  C57BL/6 mice exhibited a stronger inflammatory and fibrotic response after SCI, with increased expression of genes associated with these processes.
• 3
  Immunohistochemical analysis revealed reduced collagen IV immunostaining in the spinal lesion of spiny mice, indicating reduced fibrosis.